Complex Regulation of Adaptive and Innate Immune Responses by Wnt Ligands Affecting Autoimmunity, Asthma and Cancer

Dept. of Immunobiology

Yale Medical School

Biography

Dr. Alfred L.M. Bothwell received his AB degree from Washington University in Biology and his PhD in Biology from Yale University in Biology in Sidney Altman’s lab studying RNA biogenesis in bacteria and human cells. He did postdoctoral research at MIT in David Baltimore’s lab where he developed molecular probes for antibody genes and defined the molecular basis of the murine antibody response to the hapten NP. Once we observed the increased somatic mutation in the anti-NP antibody from a hyperimmune response compared with a primary response it was critical to further analyze B cell lineage development and somatic hypermutation (SHM). We also studied T cell dependent (TD) and T cell independent (TI) responses to NP hapten on a protein carrier and coupled to ficoll, respectively. Structural properties of many IgG genes were identified including the basis of the strain specific idiotypic anti-NP responses were identified.

Time: 15:30-16:30, June 12th (Tuesday)

Venue: Room D326, Medical Science Building

Host: Dr. Min Peng