Hai Qi, Ph.D

Phone: 86-10-62796757

Email: qihai@tsinghua.edu.cn

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The Laboratory of Hai Qi

 


Hai Qi, Ph.D.

Education:

1991 - 1996        B.M., Clinical Medicine

Beijing Medical University (Peking University Health Science Center), Beijing, China

1997 - 2003         Ph.D., Experimental Pathology

University of Texas Medical Branch, Galveston, Texas, United States

 

Employment:

2003 – 2009   Postdoctoral Fellow (Mentor: Dr. Ronald N. Germain)

                       Laboratory of Immunology, NIAID/NIH, United States

2009 – 2015   Tenure-track Associate Professor

                       School of Medicine, Tsinghua University, Beijing, China

2015 – present    Professor

                           School of Medicine, Tsinghua University, Beijing, China

 

Honors & awards:

2019    Second prize in natural science research, City of Beijing

2019    First prize in natural science research, Ministry of Education of the People's Republic of China

2018       AAI-BD Investigator Award

2017       Shulan Medical Award

2017-2022     HHMI International Research Scholar

2016       Wu Jieping-Paul Janssen Medical & Pharmaceutical Award

2016       CBIS Young Investigator Award, Chinese Biological Investigator Society

2015       “Cheung Kong Scholar" Award, Ministry of Education, China

2015       Tan Jiazhen Life Science Innovation Award

2014       “Young Talent in Science and Technology” Award, Ministry of Science & Technology of China

2014       “Distinguished Young Scientist”, National Science Foundation of China

2010       “Outstanding Talents of the New Century”, Chinese Ministry of Education

2009       “Scopus Future Star” in Life Sciences, Science News Bi-weekly and Elsevier

2003-2006     Cancer Research Institute Postdoctoral Fellowship

 

Professional activities:

2018-          Advisory Board Member, Science Immunology

2017-          Associate Editor, International Immunology

2017-           Editorial Board Member, Journal of Molecular Cell Biology

2016 - 2021 Editorial Board Member, Journal of Biological Chemistry

2011 - 2017 Editorial Board Member, Scientific Reports

2016 -          Member, American Association of Immunologists

2009 -          Chinese Society for Immunology

2009 -          Chinese Association for Laboratory Animal Sciences

 

Co-PI

Xin Liu 

Germinal Center B cell differentiation and immune memory formation

 

Post-Docs

Jinyu Zhang

 

Fate mapping of Tfh and Tfr cells

 

Huanhuan Wang 

Neural-immune regulations

 

Suhua Sun 

Neural-immune regulations

 

Ruozhu Zhao 

Sexual dimorphism in humoral immunity

 

Bo Liu 

GC organoid culture

 

Weihao Hong

 

Wen Shao 

Memory B cell biology

 

Xiaocui Luo 

Neural-immune regulation in digestive tract

 

Xiaoxiao Hou 

Memory B cell biology

 

Students

Tiange Shao 

Tissue resident memory T cell biology

 

Wenbin Chen 

TCR coinhibitory signaling

 

Qian Fang 

Humoral immune response

 

Jiacheng Wei 

Microglia

 

Li Zhang 

Neuroimmunology and cancer immunology

 

Yongshan Zhao 

Migration and maintenance of long lived plasma cells in bone marrow

 

Yihan Lin 

Follicular regulatory T cells and autoreactive GC B cells.

 

Zhiwei You 

Neuronal regulation of humoral immune response

 

Jiahui Sun 

Germinal center reaction and follicular helper T cells

 

Chengjuei Tsai 

Humoral immune response

 

Lisang Zhong 

 

Sicheng Li 

 

Siqi Guo 

 

Lab Manager

Junjun Liu

 

Alumni

Post-Docs

Longyan Wu, 2011-2019

Core facility of IITU

Tsinghua University

 

Xin Liu, 2015-2020

Co-PI

Tsinghua University

 

Xing Zhou, 2015-2021

Co-PI

Tsinghua University

 

Yifeng Wang, 2009-2021

Asistant Professor 

Changping National Lab 

 

Shiyue Hou, 2012-2021

Asistant Professor 

Xuanwu Hospital 

 

Graduate Students

ph.D.

Heping Xu, 2010-2014

Principal Investigator

Laboratory of Systems Immunology

Westlake University 

 

Xin Chen, 2010-2015

Senior research investigator

Beigene 

 

Coco Chu, 2010-2015

Postdoctoral associate

David Artis Lab

Weil Cornell Medical College

 

Jiacong Yan, 2010-2016

First People's Hospital of Yunnan Province

 

Dan Liu, 2011-2016

Postdoctoral Research Fellow

Jason Cyster Lab

UCSF

 

Hu Yan, 2011-2016

Investment manager

Trinitas Capital

 

Peiwen Lu, 2010-2017

Postdoctoral Research Fellow

Akiko Iwasaki Lab

Yale School of Medicine

 

Jingwen Shi, 2012-2018

Beigene 

 

Changming Shi, 2012-2018

Postdoctoral Research Fellow

Ng Lai Guan Lab

Singapore Immunology Network, A*STAR

 

Zurong Wan, 2012-2019

Postdoctoral Research Fellow

Virginia Pascual Lab

Weill Cornell Medical College

 

Xu Zhang, 2011-2020

Postdoctoral Research Fellow

Bart De Strooper Lab

KU Leuven

 

Xingya Ni, 2013-2020

 

Xingxing Shao, 2015-2021

 

Master

Weiwei Ma, 2011-2015

Imperial College London

 

Juan Feng, 2014-2017

Research scientist

Chongqing University Cancer Hospital

Humoral immune regulation, particularly in the following areas:

1. Molecular mechanisms governing cell-cell interactions in Germinal center reaction;

2. How cell fate determination in Germinal centers is controlled by the qualitative and quantitative parameters of cell-cell interactions;

3. Molecular mechanisms regulating the spatial-temporal organization of B cell follicles and germinal centers;

4. How the three layers of regulations described above is coordinated to ensured efficient humoral immune response but at the same time prevent autoimmunity;

5. Molecular mechanisms regulating differentiation and maintenance of memory B cells and long-lived plasma cells;

6. Regulation of immune response by the central nervous system.

 

We are also interested in studying:

7. Sexual dimorphism in immune response;

8. Differentiation of tissue resident CD8 T cells;

9. Microglia biology.

 

ORCID: 0000-0001-5475-3989

 

Bibliography: (# corresponding author; * co-first authors)

  1. 1. Bo Liu, Yihan Lin, Jiacong Yan, Jiacheng Yao, Dan Liu, Weiwei Ma, Jianbin Wang, Wanli Liu, Chengshuo Wang, Luo Zhang, and Hai Qi#. Affinity-coupled CCL22 promotes positive selection in germinal centres. Nature, 202 (DOI: 10.1038/s41586-021-03239-2)
  2. 2. Hai Qi. New twists in humoral immune regulation by SLAM family receptors. Journal of Experimental Medicine, 218 (3): e20202300, 2021. (Commentary)
  3. 3. Xingya Ni*, Yifeng Wang*, Pei Wang, Coco Chu, Heping Xu, Jinzhi Hu, Jiahui Sun, and Hai Qi#. Death associated protein kinase 2 suppresses T-B interactions and GC formation. Molecular Immunology, 2020. (DOI: 10.1016/j.molimm.2020.10.018)
  4. 4. Xu Zhang*, Bo Lei*, Yuan Yuan*, Li Zhang*, Lu Hu, Sen Jin, Bilin Kang, Xuebin Liao, Wenzhi Sun, Fuqiang Xu, Yi Zhong#, Ji Hu# and Hai Qi#. Brain control of humoral immune responses amenable to behavioral modulation. Nature, 581:204-208, 2020.
  5. 5. Ruozhu Zhao, Xin Chen, Weiwei Ma, Jinyu Zhang, Jie Guo, Xiu Zhong, Jiacheng Yao, Jiahui Sun, Julian Rubinfien, Xuyu Zhou, Jianbin Wang and Hai Qi#. A GPR174-CCL21 module imparts sexual dimorphism to humoral immunity. Nature, 577:416-420, 2020.
  6. 6. Zurong Wan, Yihan Lin, Yongshan Zhao, and Hai Qi#. TFH cells in bystander and cognate interactions with B cells. Immunological Reviews, 288:28-36, 2019.
  7. 7. Zurong Wan, Xingxing Shao, Xingyu Ji, Lihui Dong, Jiacheng Wei, Zhuqing Xiong, Wanli Liu and Hai Qi#. Transmembrane domain-mediated Lck association underlies bystander and costimulatory ICOS signaling. Cellular & Molecular Immunology, 2018. (DOI: 10.1038/s41423-018-0183-z).
  8. 8. Xiangjun Chen, Xiaolin Sun, Wei Yang, Bing Yang, Xiaozhen Zhao, Shuting Chen, Lili He, Hui Chen, Changmei Yang, Le Xiao, Zai Chang, Jianping Guo, Jing He, Fuping Zhang, Fang Zheng, Zhibin Hu, Zhiyong Yang, Jizhong Lou, Wenjie Zheng, Hai Qi, Chenqi Xu, Hong Zhang, Hongying Shan, Xujie Zhou, Qingwen Wang, Yi Shi, Luhua Lai, Zhanguo Li#, and Wanli Liu#. An autoimmune disease variant of IgG1 modulates B-cell activation and differentiation. Science, 362:700-705, 201
  9. 9. Jingwen Shi, Shiyue Hou, Qian Fang, Xin Liu, Xiaolong Liu, and Hai Qi#. PD-1 controls follicular T helper cell positioning and function. Immunity, 49:264-274, 2018.
  10. 10. Jing Wang, Sichen Liu, Baidong Hou, Meixiang Yang, Zhongjun Dong, Hai Qi, Wanli Liu. PTEN-regulated AID transcription in germinal center B cells is essential for the class-switch recombination and IgG antibody responses. Frontiers in Immunology, 9:371, 2018.
  11. 11. Juan Feng, Xin Liu, Xingya Ni and Hai Qi#. External signals regulate germinal center fate-determining transcription factors in the A20 lymphoma cell line. Molecular Immunology, 93:79-86, 2018.
  12. 12. Hai Qi. Nervous crosstalk to make antibodies. Nature, 547:288-290, 2017 (Commentary; July 12, 2017 AOP, doi:10.1038/nature23097).
  13. 13. Chenguang Xu, Hengyi Xie, Xingdong Guo, Haipeng Gong, Lei Liu, Hai Qi, Chenqi Xu, Wanli Liu. A PIP2-derived amplification loop fuels the sustained initiation of B cell activation. Science Immunology, 2:eaan0787, 2017.
  14. 14. Yifeng Wang*, Jingwen Shi*, Jiacong Yan*, Zhengtao Xiao, Xiaoxiao Hou, Peiwen Lu, Shiyue Hou, Tianyang Mao, Wanli Liu, Yuanwu Ma, Lianfeng Zhang, Xuerui Yang and Hai Qi#. Germinal center development of memory B cells driven by Interleukin-9-producing follicular T-helper cells. Nature Immunology, 18:921-930, 2017 (June 26, 2017 Epub ahead of print, doi:10.1038/ni.3788).
  15. 15. Peiwen Lu*, Changming Shih*, and Hai Qi#. Ephrin B1–mediated repulsion and signaling control germinal center T cell territoriality and function. Science, 356:eaai9264, 2017. (April 13, 2017 Epub ahead of print, doi:10.1126/science.aai9264).
  16. 16. Changming Shih and Hai Qi#. Intravital microscopy of T-B cell interactions in germinal centers. Methods in Molecular Biology, 1623:73-85, 2017
  17. 17. Hu Yan*, Longyan Wu*, Changming Shih, Shiyue Hou, Jingwen Shi, Tianyang Mao, Wenbin Chen, Bhavani Melvin, Robert J. Rigby, Yingjia Chen, Haochen Jiang, Roland H. Friedel, Carola G. Vinuesa, and Hai Qi#. Plexin B2 and Semaphorin 4C guide T-cell recruitment and function in the germinal center. Cell Reports, 19:995-1007, 20
  18. 18. Jiacong Yan, Bo Liu, Yan Shi, Hai Qi#. Class II MHC-independent suppressive adhesion of dendritic cells by regulatory T cells in vivo. Journal of Experimental Medicine, 214:319, 2017.
  19. 19. Jiahuan Chen, Anutosh Ganguly, Ashley Mucsi, Junchen Meng, Jiacong Yan, Zongde Zhang, Pascal Detampel, Fay Munro, Mei Wu, Melanie Stenner, Wencheng Zheng, Paul Kubes, Matthias Amrein, Hai Qi, Aswin Hari, Tie Xia, Yan Shi. Strong adhesion by regulatory T cells induces dendritic cell cytoskeletal polarization and contact-dependent lethargy. Journal of Experimental Medicine, 214:327, 2017.
  20. 20. Hai Qi#. T follicular helper cells in space-time. Nature Reviews Immunology, 16:612-625, 2016.
  21. 21. Ran He*, Shiyue Hou*, Cheng Liu*, Anli Zhang, Qiang Bai, Miao Han, Yu Yang, Gang Wei, Ting Shen, Xinxin Yang, Lifan Xu, Xiangyu Chen, Yaxing Hao, Chuhong Zhu, Juanjuan Ou, Houjie Liang, Ting Ni, Xiaoyan Zhang, Xinyuan Zhou, Jianqing Xu#, Hai Qi#, Yuzhang Wu# and Lilin Ye#. Follicular CXCR5-expressing CD8 T cells curtail chronic viral infection. Nature, 537:412-428, (2016).
  22. 22. Peng Wang, Chang-ming Shih, Hai Qi#, Yue-heng Lan#. A stochastic model of the germinal center integrating local antigen competition, individualistic T-B interactions and BCR signaling. Journal of Immunology, 197:1169-1182, 2016 (July 15, doi:10.4049/jimmunol.1600411).
  23. 23. Shan Tang, Zhengpeng Wan, Yiren Gao, Ji-Shen Zheng, Jing Wang, Yan-Yan Si, Xin Chen, Hai Qi, Lei Liu, Wanli Liu. Total chemical synthesis of photoactivatable proteins for light-controlled manipulation of antigen–antibody interactions. Chemical Science (Jan 2016, doi:10.1039/C5SC03404C).
  24. 24. Xiangjun Chen, Weiling Pan, Yinqiang Sui, Hua Li, Xiaoshan Shi, Xingdong Guo, Hai Qi, Chenqi Xu, and Wanli Liu. Acidic phospholipids govern the enhanced activation of IgG-B cell receptor. Nature Communications 6:8552, 2015 (Oct 6, doi: 10.1038/ncomms9552).
  25. 25. Xin Chen*#, Weiwei Ma*, Tingxin Zhang, Longyan Wu, and Hai Qi#. Phenotypic Tfh development promoted by CXCR5-controlled re-localization and IL-6 from radiation-resistant cells. Protein & Cell 6:825-832, 2015 (Sept 24, 2015 Epub ahead of print, doi:10.​1007/​s13238-015-0210-0).
  26. 26. Weiwei Ma*#, Ruozhu Zhao*, Runqing Yang, Bo Liu, Xin Chen, Longyan Wu, and Hai Qi#. Nuclear receptors of the NR4A family are not required for the development and function of follicular T helper cells. International Immunopharmacology 28:841-845, 2015 (April 18, 2015 Epub ahead of print, doi:10.1016/j.intimp.2015.04.012).
  27. 27. Xin Chen*, Shan Tang*, Ji-Shen Zheng*, Ruozhu Zhao, Zhi-Peng Wang, Wen Shao, Hao-Nan Chang, Jing-Yuan Cheng, Hui Zhao, Lei Liu#, and Hai Qi#. Chemical synthesis of a two-photon-activatable chemokine and photon-guided lymphocyte migration in vivo. Nature Communications 6:7220, 2015 (May 26, doi: 10.1038/ncomms8220).
  28. 28. Dan Liu*, Heping Xu*, Changming Shih, Zurong Wan, Xiaopeng Ma, Weiwei Ma, Dan Luo, and Hai Qi#. T-B-cell entanglement and ICOSL-driven feed-forward regulation of germinal centre reaction. Nature, 517:214-218, 2015 (Oct 15, 2014 Epub ahead of print, doi:10.1038/nature13803).
  29. 29. Coco Chu, Yifeng Wang, Xu Zhang, Xinya Ni, Junxia Cao, Wan Xu, Zhongjun Dong, Pengfei Yuan, Wensheng Wei, Yuanwu Ma, Lianfeng Zhang, Longyan Wu, and Hai Qi#. SAP-regulated T cell-APC adhesion and ligation-dependent and -independent Ly108-CD3z interactions. Journal of Immunology, 193:3860-3871, 2014 (Sep 12, Epub ahead of print, doi:10.4049/jimmunol.1401660)

30. 30. Hai Qi#, Xin Chen, Coco Chu, Dan Liu, Weiwei Ma, Yifeng Wang, Longyan Wu, Hu Yan, and Jiacong Yan. Tfh cell differentiation and their function in promoting B-cell responses. Advances in Experimental Medicine and Biology, 841:153-180, 2014

  1. 31. Hai Qi#, Wolfgang Kastenmuller# and Ronald N Germain#. Spatio-temporal basis of innate and adaptive immunity in secondary lymphoid tissue. Annual Review of Cell and Developmental Biology, 30:141-167, 2014 (Aug 8, Epub ahead of print, doi: 10.1146/annurev-cellbio-100913-013254)
  2. 32. Hai Qi#, Dan Liu, Weiwei Ma, Yifeng Wang, Hu Yan. Bcl-6 controlled TFH polarization and memory: the known unknowns. Current Opinion in Immunology, 28:34-41, 2014
  3. 33. Junjiao Yang, Yuan Zhang, Pengfei Yuan, Yuexin Zhou, Changzu Cai, Qingpeng Ren, Dingqiao Wen, Coco Chu, Hai Qi, and Wensheng Wei. Complete decoding of TAL effectors for DNA recognition. Cell Research, 24:628-631, 2014
  4. 34. Xindong Liu, Xin Chen, Bo Zhong, Yaoqi Alan Wang, Xiaohu Wang, Fuliang Chu, RozaNurieva, Xiaowei Yan, Ping Chen, Laurens van der Flier, Hiroko Nakatsukasa, SattvaNeelapu, Wanjun Chen, Hans Clevers, Qiang Tian, Hai Qi, Lai Wei, and Chen Dong. Transcription factor Achaete-Scute homologue 2 initiates T follicular helper cell development. Nature, 507:513-518, 2014
  5. 35. Longyan Wu, Peiwen Lu, Weiwei Ma, Coco Chu, Heping Xu, and Hai Qi#. Identification of a new isoform of the murine Sh2d1a gene and its functional implications. Science China Life Sciences 57: 1–7, 2014.
  6. 36. Hai Qi#, Xin Chen, CoCo Chu, Peiwen Lu, Heping Xu, and Jiacong Yan. Follicular T-helper cells: controlled localization and cellular interactions. Immunology & Cell Biology, 92:28-33, 2014.
  7. 37. Seung Goo Kang*, Wen-Hsien Liu*, Peiwen Lu*, Hyun Yong Jin, Hyung W Lim, Jovan Shepherd, Daniel Fremgen, Eric Verdin, Michael B A Oldstone, Hai Qi, John R Teijaro, and Changchun Xiao. MiR-17~92 family microRNAs are critical regulators of T Follicular helper cell differentiation. Nature Immunology 14:849-57, 2013. (* co-first authors)
  8. 38. Heping Xu, Xuanying Li, Dan Liu, Jianfu Li, Xu Zhang, Xin Chen, Shiyue Hou, Lixia Peng, Chenguang Xu, Wanli Liu, Lianfeng Zhang, and Hai Qi#. Follicular T-helper cell recruitment governed by bystander B cells and ICOS-driven motility. Nature 496:523-527, 2013.
  9. 39. Hai Qi#. From SAP-less T cells to helpless B cells and back: dynamic T-B interactions in germinal center development. Immunological Reviews 247:24-35, 2012.
  10. 40. Roza I. Nurieva, Andrew Podd, Yuhong Chen, Andrei M. Alekseev, Mei Yu, Xiaopeng Qi, Hua Huang, Renren Wen, Junmei Wang, Haiyan S. Li, Stephanie S. Watowich, Hai Qi, Chen Dong, and Demin Wang. STAT5 negatively regulates T follicular helper (Tfh) cell generation and function. Journal of Biological Chemistry 287:11234-9, 2012.
  11. 41. Yin Liu, Natalya V. Belkina, Chung Park, Raj Nambiar, Scott M. Loughhead, GenaroPatino-Lopez, Khadija Ben-Aissa, Jian-Jiang Hao, Michael J. Kruhlak, Hai Qi, Ulrich H. von Andrian, John H. Kehrl, Matthew J. Tyska, and Stephen Shaw. Constitutively active ezrin increases membrane tension, slows migration, and impedes endothelial transmigration of lymphocytes in vivo in mice. Blood 119:445-453, 2012.
  12. 42. Jennifer L. Cannons, Hai Qi, Kristina T. Lu, Mala Dutta, Julio Gomez-Rodriguez, Jun Cheng, Edward K. Wakeland, Ronald N. Germain, and Pamela L. Schwartzberg. Optimal Germinal Center Responses Require A Multistage T Cell: B Cell Adhesion Process Involving Integrins, SLAM-Associated Protein, and CD84. Immunity 32:253, 2010.
  13. 43. Frederick Klauschen, Masaru Ishii, Hai Qi, Marc Bajénoff, Jackson G Egen, Ronald N Germain, and Martin Meier-Schellersheim. Quantifying cellular interaction dynamics in 3D fluorescence microscopy data. Nature Protocols 4:1305-11, 2009.
  14. 44. Frederick Klauschen, Hai Qi, Jackson G Egen, Ronald N Germain, and Martin Meier-Schellersheim. Computational reconstruction of cell and tissue surfaces for modeling and data analysis. Nature Protocols 4:1006-1012, 2009.
  15. 45. Pamela L. Schwartzberg, Kristen L. Mueller, Hai Qi, and Jennifer L. Cannons. SLAM receptors and SAP influence lymphocyte interactions, development and function. Nature Reviews Immunology 9:39-46, 2009.
  16. 46. Hai Qi*, Jennifer L. Cannons*, Frederick Klauschen, Pamela L. Schwartzberg, and Ronald N. Germain. SAP-controlled T-B cell interactions underlie germinal centre formation. Nature 455:764-769, 2008. (* co-first authors)
  17. 47. Ronald N. Germain, Marc Bajénoff, Flora Castellino, Marcello Chieppa, Jackson G. Egen, Alex Y. C. Huang, Masaru Ishii, Lily Y. Koo, and Hai Qi. Making friends in out-of-the-way places: how cells of the immune system get together and how they conduct their business as revealed by intravital imaging. Immunological Reviews 221:163-181, 2008.
  18. 48. Marc Bajénoff, Jackson G. Egen, Hai Qi, Alex Y.C. Huang, Flora Castellino, and Ronald N. Germain. Highways, Byways, and Breadcrumbs: Directing Lymphocyte Traffic in the Lymph Node. Trends in Immunology 28:346-352, 2007.
  19. 49. Hai Qi, Jackson G. Egen, Alex Y. C. Huang, and Ronald N. Germain. Extrafollicular activation of lymph node B cells by antigen-bearing dendritic cells. Science 312:1672-1676, 2006.
  20. 50. Marc Bajénoff , Béatrice Breart, Alex Y.C. Huang, Hai Qi, Julie Cazareth, Veronique M. Braud, and Ronald N. Germain, Nicolas Glaichenhaus. NK cell behavior in lymph nodes revealed by static and real-time imaging. Journal of Experimental Medicine 203:619-631, 2006.
  21. 51. Ronald N. Germain, Flora Castellino, Marcello Chieppa, Jackson G. Egen, Alex Y.C. Huang, Lily Y. Koo, and Hai Qi. An extended vision for dynamic high-resolution intravital immune imaging. Seminars in Immunology 17:431-441, 2005.
  22. 52. Alex Y.C. Huang, Hai Qi, and Ronald N. Germain. Illuminating the landscape of in vivo immunity:  insights from dynamic in situ imaging of secondary lymphoid tissues. Immunity 21:331-339, 2004.
  23. 53. Hai Qi, JiaxiangJi, Nanchaya Wanasen and Lynn Soong. Enhanced replication of Leishmania amazonensis amastigotes in interferon-g-stimulated murine macrophages: implications for the pathogenesis of cutaneous leishmaniasis. Infection and Immunity 72:988-995, 2004.
  24. 54. Timothy L. Denning, Hai Qi, Rolf König, Kevin G. Scott, Makoto Naganuma, and Peter B. Ernst. CD4+ Th cells resembling regulatory T cells that inhibit chronic colitis differentiate in the absence of interactions between CD4 and Class II MHC. Journal of Immunology 171:2279-2286, 2003.
  25. 55. Hai Qi, Timothy L. Denning, and Lynn Soong. Differential induction of IL-10 and IL-12 in dendritic cells by microbial Toll-Like Receptor activators and the skewing of T cell cytokine profiles. Infection and Immunity 71:3337-3342, 2003.
  26. 56. Jiaxiang Ji, Jiaren Sun, Hai Qi, and Lynn Soong. Analysis of T helper cell responses during infection with Leishmania amazonensis. American Journal of Tropical Medicine & Hygiene 66:338-345, 2002.
  27. 57. S. Wesley Long, Xiao-Feng Zhang, Hai Qi, Steven Standaert, David H. Walker, and Xue-Jie Yu. Antigenic variation of Ehrlichia chaffeensis resulting from differential expression of the 28-kilodalton protein gene family. Infection and Immunity 70:1824-1831, 2002.
  28. 58. Hai Qi, Vsevolod Popov, and Lynn Soong. Leishmania amazonensis-dendritic cell interactions in vitro and the priming of parasite-specific CD4+ T cells in vivo. Journal of Immunology 167:4534-4542, 2001.

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