Phone: 86-10-62795612
Email: xiaoyuhu @ tsinghua.edu.cn
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The Laboratory of Xiaoyu Hu
Xiaoyu Hu, Ph.D.
Xiaoyu Hu received her Bachelor of Medicine degree from Peking University and obtained her Ph.D. degree in immunology from Cornell University. She held the position of tenure track Assistant Professor at Weill Cornell Medicine prior to joining Tsinghua University in 2014. Currently she is Professor at Institute for Immunology, Tsinghua University.
Dr. Hu’s research aims to better understand molecular mechanisms governing functionality of two key cell types involved in host defense and inflammatory responses, macrophages and intestinal epithelial cells (IECs). One focus of Dr. Hu’s laboratory is to uncover transcriptional, translational and metabolic mechanisms that regulate macrophage and IEC responses to pathogenic and inflammatory cues. Dr. Hu’s work has been funded by agencies including National Natural Science Foundation of China (NSFC), Minister of Science and Technology of China, U.S. National Institutes of Health (NIH R01), U.K. Royal Society, American College of Rheumatology and Lupus Research Institute and has been reported by news media such as Time Online.
Dr. Hu has authored over 60 publications including corresponding-author research articles in journals such as Immunity, Nature Immunology, Cell Host & Microbe, Science Translational Medicine, Journal of Experimental Medicine, and Nature Communications and book chapters (h-index = 33). She is the recipient of multiple awards including Christina Fleischmann Award to Young Women Investigators from International Cytokine & Interferon Society, Distinguished Young Investigator Award from NSFC, Newton Advanced Fellowship from the U.K. Royal Society and Young Scholar Award from Arthritis Foundation. Dr. Hu also serves in editorial boards of journals including Science Advances, eLife, Trends in Immunology and composed commentary articles for journal such as Immunity. She actively advocates for status and rights of female scientists by serving in diversity panels for organizations such as Society of Leukocyte Biology and composing opinion essays for journals such as Nature Immunology.
Post-Docs
Miaomiao Wang
Miaomiao Wang, received PhD degree from Autonomous University of Barcelona (UAB), and current research field is the myeloid cell-targeted therapy
王苗苗，博士毕业于巴塞罗那自治大学，目前的研究方向是髓系细胞靶向疗法
Hongzhou Zhou
我叫周鸿洲，博士毕业于北京大学。2023年9月加入Hu Lab进行博士后阶段的研究，现专注于探索肥大细胞及其产物的功能与调控。
热爱运动，喜欢长鼻子动物，喜欢大自然特别是狂风暴雨雷电。
Hongzhou Zhou
I got my PhD from Peking University and joined Hu Lab as a postdoc in September 2023. I am now focusing on the function and regulation of mast cells and its products.
I like sports and animal with long nose.
I love nature and enjoy thunder storm.
Zhi Ye
From 2015 to 2023, I spent my entire university career at Peking University, where I earned both my bachelor's and doctoral degrees from the School of Basic Medical Sciences. During my PhD, my research focuses on novel innate immune receptors and the exploration of molecular mechanisms that influence the activation of inflammasomes. Currently, I have joined the research group of Professor Hu Xiaoyu to pursue postdoctoral studies, focusing on the in-depth exploration of mast cell functions.
从2015年到2023年，我在北京大学度过了整个大学生涯，从基础医学院获得了学士和博士学位。在攻读博士学位期间，我的研究方向是新的先天免疫受体和对影响炎症小体活化的分子机制的探索。目前，我加入了胡小玉教授的研究小组，开启博士后工作，深入研究肥大细胞的功能。
Wenwen Wang
Wenwen Wang, received Ph.D from University of Science and Technology of China, and current research field is the ontogeny of intestinal myeloid cells.
王稳稳，在中国科学技术大学获得博士学位，目前集中研究肠髓系细胞的来源。
Students
Yeyang Liu
Yeyang Liu,Ph.D student (from 2021) in CLS, Bachelor’s degree from Tsinghua University, research focus: interstitial macrophage-niche interaction.
刘叶阳，2021级CLS项目博士生，本科毕业于清华大学，研究方向为探究间质巨噬细胞与微环境互作。
Yunqi Liu
刘韵琦
Ph.D student (from 2019) in School of Medicine, Bachelor’s degree from Wuhan University, research focus: resident macrophage activation in response to stress
Ph.D学生（2019级），本科毕业于武汉大学。研究方向：压力刺激下组织驻留巨噬细胞的活化
Kunpeng Yang
阳昆鹏，基础医学21级博士生，本科毕业于复旦大学。目前的研究方向是髓系细胞在二型免疫反应中的效应功能。
Kunpeng Yang, PhD student of Basic Medicine from 2021. Bachelor degree from Fudan University. The current research field is the effector functions of myeloid cells in type 2 immunity.
Ruoxi Shen
申若曦
我来自北京大学-清华大学生命科学联合中心（CLS）的申若曦。本科毕业于上海交通大学，目前主要关注上皮屏障在免疫调控中的功能。
Ruoxi Shen, a Ph.D. student from center for life sciences (CLS). I graduated with a bachelor's degree from Shanghai Jiao Tong University, and I am currently focusing on the role of epithelial barriers in immune regulation.
Hongtao Lin
林鸿滔，清华大学CLS项目2023级博士生，本科毕业于厦门大学，目前的研究方向是：小肠肥大细胞的发育。
Lin Hongtao, a Ph.D. student from center for life sciences (CLS), having earned his bachelor’s degree from Xiamen University. He currently focuses on the ontogeny of intestinal mast cells.
Haoqi Yang
Haoqi Yang, Ph.D. student at School of Basic Medicine since 2022, Bachelor’s degree from Tsinghua University. His research mainly focuses on the role of immune cells in thermoregulation.
杨皓淇自2022年起在基础医学院攻读博士学位，本科毕业于清华大学。他的研究聚焦于免疫细胞在体温调控中的作用。
Yiran Li
我本科毕业于中国科学技术大学，目前的研究主要关注髓系细胞在免疫防御中的作用。
I graduated with a bachelor's degree from the University of Science and Technology of China, and my current research primarily focuses on the role of myeloid cells in immune defense.
Xiaomin Zeng
Xiaomin Zeng, Ph. D candidate of basic medicine starting in 2018, likes running, hiking, camping and is an outdoor enthusiast. She is active and full of energy. The main research direction is how metabolic small molecules affect and regulate the tumor immune microenvironment.
Jiali Wang
王佳丽，本科毕业于东北大学，现研究方向是肠道上皮细胞的功能调节机制。
Jiali Wang, received bachelor's degree from Northeastern University, and current research field is the functional regulation mechanism of intestinal epithelial cells.
Xingxian Liu
我是刘倖衔，现在是清华基础医学院的博士生。我是土生土长的天津人，并在南开大学获得学士学位。我的博士课题主要研究巨噬细胞蛋白质翻译过程如何影响如细胞因子释放综合症在内的人炎症性疾病的发生。
I’m Xingxian Liu, a PhD student of School of Medicine, Tsinghua University. I was born and raised in Tianjin and earned my bachelor degree in Nankai University. My PhD project focuses on how macrophage translation shapes human inflammatory diseases including CRS.
Jiaqi Li
Lab Alumni
Ning Fei , Postdoctoral fellow, UCSF
Liangliang Ji, Postdoctoral fellow, Sloan Kettering Institute
Guo Xue-kun,Assistant professor, School of Clinical Medicine at Tsinghua University
Kang Lan, Postdoctoral fellow, Weill Cornell Medicine
Yu Li, Postdoctoral fellow, Tsinghua University
Liang Shaonan, Hengrui Medicine Co Ltd.
Zhang Xiang, Genetron Health (Beijing) Co. Ltd.
Bin Zhang
Jiayao Ou
Xiaoyu Li
Ziyi Guo
Yuzhuo Yang
Tiantian Kou
Mengtao Ding
Vincent Philippus van Hensbergen
Liu Yang
Xiaoyan Xing
Laboratory of Innate Effector Function
Our lab focuses on understanding the physiological and pathological functions of tissue resident myeloid cells, particularly macrophages and mast cells. Tissue resident myeloid cells are widely distributed in almost all tissues in our body and are integral components of tissues under homeostatic conditions. We aim to understand how macrophages and mast cells adapt to unique tissue microenvironments and how tissue microenvironments shape the identity and function of resident myeloid cells.
ORCID: 0000-0002-4289-6998
ResearcherID: D-5403-2017
Representative publications out of >90
1. Shang Y, Coppo M, He T, Ning F, Yu L, Kang L, Zhang B, Ju C, Qiao Y, Zhao B, Gessler M, Rogatsky I, Hu X. The transcriptional repressor Hes1 attenuates inflammation by regulating transcription elongation. Nat Immunol. 2016 Aug;17(8):930-7.
2. Guo XK, Ou J, Liang S, Zhou X, Hu X. Epithelial Hes1 maintains gut homeostasis by preventing microbiota dysbiosis. Mucosal Immunology 2018; 11:716-726
3. Liang S, Guo XK, Ou J, Huang R, Xue Q, Zhang B, Chung Y, Wu W, Dong C, Yang X, Hu X. Nutrient Sensing by the Intestinal Epithelium Orchestrates Mucosal Antimicrobial Defense via Translational Control of Hes1. Cell Host Microbe. 2019 May 8;25(5):706-718.e7.
4. Ning F, Li X, Yu L, Zhang B, Zhao Y, Liu Y, Zhao B, Shang Y*, Hu X*(*co-corresponding author). Hes1 attenuates type I IFN responses via VEGF-C and WDFY1. J Exp Med. 2019 Jun 3;216(6):1396-1410.
5. Ji L, Zhao X, Zhang B, Kang L, Song W, Zhao B, Xie W, Chen L*, Hu X*(*co-corresponding author). Slc6a8-Mediated Creatine Uptake and Accumulation Reprogram Macrophage Polarization via Regulating Cytokine Responses. Immunity. 2019 Aug 20;51(2):272-284.e7.
6. Hu X. Stereotyping in East and West: live with it or deal with it? Nat Immunol. 2020 Mar;21(3):234. (invited essay in press for the women scientist-focused issue)
7. Kang L, Zhang X, Ji L, Kou T, Smith SM, Zhao B, Guo X, Pineda-Torra I, Wu L, Hu X. The colonic macrophage transcription factor RBP-J orchestrates intestinal immunity against bacterial pathogens. J Exp Med. 2020 Apr 6;217(4):e20190762.
8. Yu L, Zhang B, Deochand D, Sacta MA, Coppo M, Shang Y, Guo Z, Zeng X, Rollins DA, Tharmalingam B, Li R, Chinenov Y, Rogatsky I*, Hu X* (*co-corresponding author). Negative elongation factor complex enables macrophage inflammatory responses by controlling anti-inflammatory gene expression. Nat Commun. 2020 May 8;11(1):2286.
9. Zhang B, Zhang Y, Xiong L, Li Y, Zhang Y, Zhao J, Jiang H, Li C, Liu Y, Liu X, Liu H, Ping YF, Zhang QC, Zhang Z, Bian XW*, Zhao Y*, Hu X*(*co-corresponding author). CD127 imprints functional heterogeneity to diversify monocyte responses in inflammatory diseases. J Exp Med. 2022 Feb 7;219(2):e20211191.
10. Liu X, Han W, Hu X. Post-transcriptional regulation of myeloid cell-mediated inflammatory responses. Advances in Immunology 2023; 160:59
11. Xing X, Hu X. Risk factors of cytokine release syndrome: stress, catecholamines, and beyond. Trends in Immunology 2023; 44:93
12. Li X, Zhang B, Zhang X, Yu S, Xue HH, Hu X. TLE3 and TLE4-coordinated colonic macrophage-CD4+ T cell crosstalk maintains intestinal immune homeostasis. Mucosal Immunol. 2023 Feb;16(1):50-60.
13. Guo X*, Wang J, van Hensbergen VP, Xu H*, Hu X* (*co-corresponding authors). Epithelial fucosylation promotes antimicrobial host defense by restraining invasive mucus-associated biofilms. Cell Reports 2023; 42:112754
14. Yang Y, Zhang Y, Xing X, Xu G, Wang Y, Chen M, Wang C, Han W*, Hu X (*co-corresponding authors). IL-6 translation is a therapeutic target of human cytokine release syndrome. Journal of Experimental Medicine 2023; 220:e20230577 (selected to be Best of JEM 2023)
15. Kou T, Kang L, Zhang B, Ji L, Zhao B, Zeng W, Hu X. RBP-J regulates homeostasis and function of circulating Ly6Clo monocytes. eLife 2024; 12, RP88135
16. Yang L, He H, Guo X, Wang J, Wang W, Liang S, Shao F, Liu W, Hu X. Intraepithelial mast cells drive Gasdermin C-mediated type 2 immunity. Immunity 2024; 57:1056
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