Phone: 86-10-62783617
Email: liulab @ mail.tsinghua.edu.cn
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The Laboratory of Wanli Liu
Wanli Liu, Ph.D.
Principal Investigator, Distinguished Young Scholar of National Natural Science Foundation of China, Distinguished Professor/Scholar of Ministry of Education, Youth Science and technology innovation leader of Ministry of Science and Technology, China.
Wanli Liu is a tenured professor and Ph.D supervisor of the School of Life Sciences of Tsinghua University, and a researcher at the Institute of Immunology of Tsinghua University and the Center for Life Sciences. Supported by the National Science Fund for Distinguished Youth, Changjiang Scholars Distinguished Professor of the Ministry of Education, and Science and Technology Innovation Leaders of the Ministry of Science and Technology. Focus on the fundamental immunology research of B lymphocytes, and devote to the integration of interdisciplinary platforms to study the pathogenic mechanism involving B cell immune recognition, immune activation and related immune diseases. Multiple corresponding paper (including co-corresponding) was published in the aspect of the regulation of lymphocyte activation and related diseases (Science, J Exp Med, Cell Research, Leukemia and eLife), new pathways of lipid metabolism network regulating lymphocyte activation (Cell, PLOS Biology, Science Immunology, Cell Reports and Nature Communications), the new mechanism of antigen receptor microclusters regulating lymphocyte activation (Science Advances, PNAS and eLife 2019b) and the new model of mechanical force sensing regulating B cell activation (J Cell Biol, Science Signaling and eLife15/17) and other research directions. Related results were selected as part of the top ten medical science and technology news in China in 2018. Won the China Youth Science and Technology Award, WuXi AppTec Life Chemistry Outstanding Achievement Award, Tan Jiazhen Life Science Innovation Award, Shulan Medical Youth Award and other awards. Invited to hold lectures at domestic and foreign academic conferences (Keystone B cell conference in 2022, Antigen Receptor Signal Transduction Biennial Conference in 2022, 2018 and 2016 EMBO Conference, 2018 American Rheumatism Annual Conference, etc.). Served as an editorial board member of the Chinese Journal of Immunology, Rheumatology & Autoimmunity, Frontiers in Immunology; reviewed scientific research projects for NSFC, MOST, NIH, UK Wellcome Trust Foundation, Dutch Research Council, etc.; by 2021, a total of 6 post-doctoral fellows and 11 graduated PhDs have been trained , 6 masters graduated.
Medical Science Building, RM-A103
Tsinghua University, Beijing, China, 100084
Tel: +86-10-62783617
Email:liulab@tsinghua.edu.cn
ProfessionalExperience
2011.12 – present , PrincipalInvestigator, School of Life Sciences, Institute for Immunology, Tsinghua University
2007 – 2011, Postdoc, NIAID, NIH, USA
2005 – 2007, Postdoc, Dept. of Microbiology/Immunology, UCSF, USA
2001 – 2005, Ph.D, Dept. of Biological Science and Biotechnology, Tsinghua University
1997 – 2001, Bachelor, School of Biology, China Agriculture University
Recognitions and Awards
2022 The second prize of China Medical Science and Technology Award
2022 The second prize of natural science of Hubei Province (the second winner)
2021 The second prize of the natural science award of the Ministry of Education (the second winner)
2021 First prize of Beijing Medical Science and Technology Award (the second winner)
2021 2021 excellent patent of China bioengineering Society (first inventor)
2020 Young Science & Technology Award, China
2019 WuXi AppTec Outstanding Achievement Award, China
2019 C.C. Tan (Tan JZ) Life Science Innovation Award, China
2019 Newton Advanced Scholar/Fellowship, The Royal Society, UK
2019 Cheung Kong Distinguished Professor/Scholar
2019 Asian Universities Alliance Scholar, Asian Universities Alliance
2019 Tsinghua-Bayer Investigator Award
Post-Docs
Na Kang
Postdoctoral fellow of Wanli Liu’s lab~ Sport girl who loves experiments.
Zhenglin Ji
Cuifeng Li
Shaocun Zhang
Color my life with the chaos of trouble.
Students
Yu Wang
We're all playing the same game,waiting on our loan.
Ji Gao
From Zhuzhou, Hunan province, still studying.
Qinghui Duan
Qinghui Duan (2020 class)
Email:dqh20@mails.tsinghua.edu.cn
Shandong University, B.S.(2016-2020)
Center for Life Sciences, Tsinghua University, (2020- )
Research Areas: Molecular immunology, cell biology
Ruiyu Gao
Comes from Jinan, Shandong province. She graduated from Shandong Normal University with a bachelor's degree in biological science. She graduated from Peking Union Medical College with a master's degree in biochemistry and molecular biology. In 2020, she entered Tsinghua University through the PTN program to study for a doctorate, and was assigned to Wanli Liu's lab. Her current research interest is tumor antigen specific antibody response.
Yuxiao Zhang
Grade 2020
Xin Min
Grade 2021
Tong Li
Grade 2022
Xiaohang Liu
Grade 2022
Jiachen Zhang
Grade 2022
Yuheng Huang
Grade 2023
Lab Alumni
Zhengpeng Wan
Asma Ahsan
Shuting Chen
Jing Wang
Zhixun Shen
Xingwang Zhao
Samina Shaheen
Yingjia Chen
Yan Fang
Xuejiao Dong
Zongyu Li
Hengyi Xie
Xinxin Li
Han Li
Meng Zhao
Bing Yang
Jing Chen
Sichen Liu
Xingyu Ji
Yuxin Li
Xiaoyang Zhang
Can Zhu
Yongjie Zhu
Wenbo Sun
We combine immunological and biochemical experimental approaches with cutting-edge high resolution high speed live cell and molecule imaging techniques to investigate the function of lymphocyte cells. We are working on the studies of: (1) Lymphocytes activation and regulation; (2) Immune-diseases induced by abnormal lymphocyte activation; (3) Immunological memory; (4) Mechanosensing biology of lymphocytes; (5) Immune-evasion; (6) Next generation vaccines based on the new understanding of lymphocyte activation and function.
ORCID: 0000-0003-0395-2800
ResearcherID:
Representative Research articles and Reviews (*, corresponding author):
[1] Cuifeng Li#, Meng Zhao#, Xiaohang Liu#, Yuxin Li#, Bihua Xu#, Lina Zhou#, Xiaolin Sun#, Wenbo Sun, Na Kang, Zhenglin Ji, Tong Li, Haoran An, Fei Wang, Chuan Wu, Jing-Ying Ye, Jing-Ren Zhang*, Qingwen Wang*, Xiaodong Zhao*, Zhanguo Li*, Wanli Liu*. Ion channel TRPV2 is critical in enhancing B cell activation and function. J Exp Med. 2024, doi: 10.1084/jem.20221042.
[2] Bing Yang#, Zhen Zhang#, Xiangjun Chen#, Xu-Yan Wang, Shishang Qin, Liaoqi Du, Changjiang Yang, Liyu Zhu, Wenbo Sun, Yongjie Zhu, Qinwen Zheng, Shidong Zhao, Quan Wang, Long Zhao, Yilin Lin, Jinghe Huang, Fan Wu, Lu Lu, Fei Wang, Wenjie Zheng, Xiao-Hua Zhou, Xiaozhen Zhao, Ziye Wang, Sun Xiao-Lin, Yingjiang Ye, Shan Wang, Zhanguo Li, Hai Qi, Zemin Zhang, Dong-Ming Kuang, Lei Zhang, Zhanlong Shen*, Wanli Liu*. An Asian-specific variant in human IgG1 represses colorectal tumorigenesis by shaping the tumor microenvironment. J Clin Invest. 2022, e153454. doi: 10.1172/JCI153454.
[3] Xingwang Zhao#, Hengyi Xie#, Meng Zhao#, Asma Ahsan, Xinxin Li, Fei Wang, Junyang Yi, Zhiyong Yang, Chuan Wu, Indu Raman, Quan-Zhen Li*, Tae Jin Kim*, Wanli Liu*. Fc receptor-like 1 intrinsically recruits c-Abl to enhance B cell activation and function. Science Advances. 2019, 5, eaaw0315, DOI: 10.1126/sciadv.aaw0315
[4] Chenguang Xu#, Yan Fang#, Zhiyong Yang, Yukai Jing, Yonghui Zhang, Chaohong Liu*, Wanli Liu*. MARCKS regulates tonic and chronic active B cell receptor signaling. Leukemia. 2019, 33:710-729.
[5] Xiangjun Chen, Xiaolin Sun#, Wei Yang#, Bing Yang#, Xiaozhen Zhao, Shuting Chen1, Lili He, Hui Chen, Changmei Yang, Le Xiao, Zai Chang, Jianping Guo, Jing He, Fuping Zhang, Fang Zheng, Zhibin Hu, Zhiyong Yang, Jizhong Lou, Wenjie Zheng, Hai Qi, Chenqi Xu, Hong Zhang, Hongying Shan, Xu-jie Zhou, Qingwen Wang, Yi Shi, Luhua Lai, Zhanguo Li *, Wanli Liu*. An autoimmune disease variant of IgG1 modulates B-cell activation and differentiation. Science. 2018, 362:700-705.
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