Phone: 010-62782882
Email: pengmin@tsinghua.edu.cn
履历
2017-至今 清华大学医学院助理教授
2017-至今 清华大学免疫学研究所研究员
2017-至今 清华-北大生命科学联合中心研究员
2014-2017 美国纪念斯隆凯特琳癌症中心免疫系副研究员
2010-2014 美国纪念斯隆凯特琳癌症中心免疫系博士后
2005-2010 北京协和医学院免疫学专业博士
2000-2005四川大学华西医学院临床医学专业学士
奖励或奖项
2019 2019年度“求是杰出青年学者奖”
2018 拜耳研究员奖
2015 纪念斯隆凯特琳癌症中心博士后研究奖
实验室成员:
刘莹 2014级
赵翰飞 2017级
张光跃 2017级
金刚 2017级
马玉莹 2018级
许靖 2018级
何子豪 2019级
余韫 2020级
刘岩岩 2020级
马晓南 2020级
T cells play essential roles in immune response. We are studying T cells with two directions:
1. Functional genomics in primary T cells
We are applying genome-wide CRISPR/Cas9 screen in primary T cell in vivo to answer fundamental questions in T cell biology, including development, activation, proliferation and differentiation, as well as T cell fitness (e.g. exhaustion) in tumor microenvironment. Identified novel genes and regulatory circuits have been used to design novel therapies for diseases.
2. Mechanisms of metabolic regulation of T cells
Metabolic reprogramming is a hallmark of T cell activation, but how metabolic pathways regulate T cell function remains poorly understood. We are using mouse models with gain- and loss-of-function of key metabolic enzymes to decipher metabolic regulation T cell, and try to target metabolism to treat immune-related diseases.
ORCID: 0000-0002-5885-0660
ResearcherID: O-3770-2017
代表性论著:
1. Min Peng, Na Yin, Ming O. Li. SZT2 dictates GATOR control of mTORC1 signaling. Nature. 2017 Mar 16;543(7645):433-437.
2. Min Peng*, Na Yin*, Sagar Chhangawala, Ke Xu, Christina S. Leslie, Ming O. Li. Aerobic glycolysis promotes T helper 1 cell differentiation through an epigenetic mechanism. Science, 2016 Oct 28; 354(6311): 481-484. *equal contribution.
Preview in Science, 2016 Oct 28; 354(6311): 419-420. “Warburg meets epigenetics”.
Preview in Dev Cell, 2016 November 7;39: 286-287. “Metabolic Control of Cellular Differentiation”.
Preview in Cell Metab, 2016 November 8; 24: 651-652. “Metabolic Signaling Drives IFN-g”.
3. Jiangbin Ye, Wilhelm Palm, Min Peng, Bryan King, Tullia Lindsten, Ming O. Li, Constantinos Koumenis, Craig B. Thompson. GCN2 sustains mTORC1 suppression upon amino acid deprivation by inducing Sestrin2. Genes Dev. 2015 Nov 15; 29 (22): 2331-6.
4. Min Peng, Na Yin, Ming O. Li. Sestrins Function as Guanine Nucleotide Dissociation Inhibitors for Rag GTPases to Control mTORC1 Signaling. Cell. 2014 Sep 25; 159(1): 122-33.
Highlighted in Nat Rev Mol Cell Biol, 2014; 15: 701, “A RAG dissociation inhibitor”.
5. Weiming Ouyang, Will Liao, Chong T. Luo, Na Yin, Morgan Huse, Myoungjoo V. Kim, Min Peng, Pamela Chan, Qian Ma, Yifan Mo, Dies Meijer, Keji Zhao, Alexander Y. Rudensky, Gurinder Atwal, Michael Q. Zhang, Ming O. Li. Novel Foxo1-dependent transcriptional programs control Treg cell function. Nature. 2012 Nov 22; 491(7425): 554-9.
版权所有©2017 清华大学免疫学研究所
地址:清华大学医学楼D302,北京,100084
电话:010-62776420 传真:010-62776420