教育背景:
1991 – 1996 学士,临床医学 北京医科大学
1997 – 2003 博士,实验病理学 德克萨斯州加尔韦斯顿医学院 (University of Texas Medical Branch at Galveston, Texas, United States)
工作经历:
1997 – 2003 研究助理 (导师:Dr. Lynn Soong)
德克萨斯州加尔韦斯顿医学院
2003 –2009 博士后研究员 (导师:Dr. Ronald N. Germain)
免疫实验室,美国国立卫生研究院传染病与变态反应病研究所 (Laboratory of Immunology, NIAID/NIH)
2009 –2015 副教授(Tenure-track),清华大学
2015 – 教授(Tenured),清华大学
专业活动:
2019- Allergy 编委
2018- 科学顾问, Science Immunology
2017-2020 国家自然科学基金委员会医学部第四届专家咨询委员会委员
2017- 副主编, International Immunology
2017- Journal of Molecular Cell Biology 编委
2016 - 2021 Journal of Biological Chemistry编委
2015 - 2019 《科技导报》编辑委员会委员
2015 澳大利亚墨尔本大学教授晋升评审人
2014 英国Wellcome Trust 科研基金评审人
2012 - Nature, Science, Immunity, J. Exp. Med. 独立审稿人
2011 - 2017 Nature在线Scientific Reports编委
2009 - 中国免疫学会
2009 - 中国实验动物学会
2000- 美国免疫学会(American Association of Immunologists)
奖励与荣誉:
2019 北京市自然科学奖二等奖(第一完成人)
2019 教育部高等学校科学研究优秀成果奖——自然科学一等奖(第一完成人)
2018 美国免疫学会研究者奖(AAI-BD Investigator Award)
2017 树兰医学青年奖
2017 药明康德生命化学研究奖
2017 霍华德休斯医学研究所国际学者(HHMI International Research Scholar)
2016 吴阶平-保罗杨森医学药学奖
2016 第十一届华人生物学家协会“青年奖”
2015 教育部“长江学者”特聘教授
2015 谈家桢生命科学创新奖
2014 科技部“中青年科技创新领军人才”
2014 国家“杰出青年”基金获得者
2013 科技部“973”计划首席科学家
2013 清华大学“先进工作者”
2013 “科学研究优秀人才”,《中国细胞生物学学报》
2013 清华大学“学术新人奖”
2010 教育部2009年度“新世纪优秀人才”
2009 “Scopus未来科学之星”金奖,《科学新闻》与 Elsevier
2003-2006 Cancer Research Institute Postdoctoral Fellowship
2001-2003 McLaughlin Predoctoral Fellowship
2000 Young Investigator Award (Honorable mention)
American Society of Tropical Medicine and Hygiene.
实验室成员:
邵天歌 2015级
陈文斌 2015级
张厉 2016级
方谦 2016级
魏嘉程 2016级
赵咏珊 2017级
林艺涵 2017级
孙佳慧 2018级
尤志伟 2018级
蔡承叡 2019级
钟丽桑 2019级
李思成 2021级
郭思琪 2021级
ORCID: 0000-0001-5475-3989
ResearcherID:A-3955-2009
代表性论著(# 通讯作者,*共同第一作者):
- 1. Bo Liu, Yihan Lin, Jiacong Yan, Jiacheng Yao, Dan Liu, Weiwei Ma, Jianbin Wang, Wanli Liu, Chengshuo Wang, Luo Zhang, and Hai Qi#. Affinity-coupled CCL22 promotes positive selection in germinal centres. Nature, 202 (DOI: 10.1038/s41586-021-03239-2)
- 2. Hai Qi. New twists in humoral immune regulation by SLAM family receptors. Journal of Experimental Medicine, 218 (3): e20202300, 2021. (Commentary)
- 3. Xingya Ni*, Yifeng Wang*, Pei Wang, Coco Chu, Heping Xu, Jinzhi Hu, Jiahui Sun, and Hai Qi#. Death associated protein kinase 2 suppresses T-B interactions and GC formation. Molecular Immunology, 2020. (DOI: 10.1016/j.molimm.2020.10.018)
- 4. Xu Zhang*, Bo Lei*, Yuan Yuan*, Li Zhang*, Lu Hu, Sen Jin, Bilin Kang, Xuebin Liao, Wenzhi Sun, Fuqiang Xu, Yi Zhong#, Ji Hu# and Hai Qi#. Brain control of humoral immune responses amenable to behavioral modulation. Nature, 581:204-208, 2020.
- 5. Ruozhu Zhao, Xin Chen, Weiwei Ma, Jinyu Zhang, Jie Guo, Xiu Zhong, Jiacheng Yao, Jiahui Sun, Julian Rubinfien, Xuyu Zhou, Jianbin Wang and Hai Qi#. A GPR174-CCL21 module imparts sexual dimorphism to humoral immunity. Nature, 577:416-420, 2020.
- 6. Zurong Wan, Yihan Lin, Yongshan Zhao, and Hai Qi#. TFH cells in bystander and cognate interactions with B cells. Immunological Reviews, 288:28-36, 2019.
- 7. Zurong Wan, Xingxing Shao, Xingyu Ji, Lihui Dong, Jiacheng Wei, Zhuqing Xiong, Wanli Liu and Hai Qi#. Transmembrane domain-mediated Lck association underlies bystander and costimulatory ICOS signaling. Cellular & Molecular Immunology, 2018. (DOI: 10.1038/s41423-018-0183-z).
- 8. Xiangjun Chen, Xiaolin Sun, Wei Yang, Bing Yang, Xiaozhen Zhao, Shuting Chen, Lili He, Hui Chen, Changmei Yang, Le Xiao, Zai Chang, Jianping Guo, Jing He, Fuping Zhang, Fang Zheng, Zhibin Hu, Zhiyong Yang, Jizhong Lou, Wenjie Zheng, Hai Qi, Chenqi Xu, Hong Zhang, Hongying Shan, Xujie Zhou, Qingwen Wang, Yi Shi, Luhua Lai, Zhanguo Li#, and Wanli Liu#. An autoimmune disease variant of IgG1 modulates B-cell activation and differentiation. Science, 362:700-705, 201
- 9. Jingwen Shi, Shiyue Hou, Qian Fang, Xin Liu, Xiaolong Liu, and Hai Qi#. PD-1 controls follicular T helper cell positioning and function. Immunity, 49:264-274, 2018.
- 10. Jing Wang, Sichen Liu, Baidong Hou, Meixiang Yang, Zhongjun Dong, Hai Qi, Wanli Liu. PTEN-regulated AID transcription in germinal center B cells is essential for the class-switch recombination and IgG antibody responses. Frontiers in Immunology, 9:371, 2018.
- 11. Juan Feng, Xin Liu, Xingya Ni and Hai Qi#. External signals regulate germinal center fate-determining transcription factors in the A20 lymphoma cell line. Molecular Immunology, 93:79-86, 2018.
- 12. Hai Qi. Nervous crosstalk to make antibodies. Nature, 547:288-290, 2017 (Commentary; July 12, 2017 AOP, doi:10.1038/nature23097).
- 13. Chenguang Xu, Hengyi Xie, Xingdong Guo, Haipeng Gong, Lei Liu, Hai Qi, Chenqi Xu, Wanli Liu. A PIP2-derived amplification loop fuels the sustained initiation of B cell activation. Science Immunology, 2:eaan0787, 2017.
- 14. Yifeng Wang*, Jingwen Shi*, Jiacong Yan*, Zhengtao Xiao, Xiaoxiao Hou, Peiwen Lu, Shiyue Hou, Tianyang Mao, Wanli Liu, Yuanwu Ma, Lianfeng Zhang, Xuerui Yang and Hai Qi#. Germinal center development of memory B cells driven by Interleukin-9-producing follicular T-helper cells. Nature Immunology, 18:921-930, 2017 (June 26, 2017 Epub ahead of print, doi:10.1038/ni.3788).
- 15. Peiwen Lu*, Changming Shih*, and Hai Qi#. Ephrin B1–mediated repulsion and signaling control germinal center T cell territoriality and function. Science, 356:eaai9264, 2017. (April 13, 2017 Epub ahead of print, doi:10.1126/science.aai9264).
- 16. Changming Shih and Hai Qi#. Intravital microscopy of T-B cell interactions in germinal centers. Methods in Molecular Biology, 1623:73-85, 2017
- 17. Hu Yan*, Longyan Wu*, Changming Shih, Shiyue Hou, Jingwen Shi, Tianyang Mao, Wenbin Chen, Bhavani Melvin, Robert J. Rigby, Yingjia Chen, Haochen Jiang, Roland H. Friedel, Carola G. Vinuesa, and Hai Qi#. Plexin B2 and Semaphorin 4C guide T-cell recruitment and function in the germinal center. Cell Reports, 19:995-1007, 20
- 18. Jiacong Yan, Bo Liu, Yan Shi, Hai Qi#. Class II MHC-independent suppressive adhesion of dendritic cells by regulatory T cells in vivo. Journal of Experimental Medicine, 214:319, 2017.
- 19. Jiahuan Chen, Anutosh Ganguly, Ashley Mucsi, Junchen Meng, Jiacong Yan, Zongde Zhang, Pascal Detampel, Fay Munro, Mei Wu, Melanie Stenner, Wencheng Zheng, Paul Kubes, Matthias Amrein, Hai Qi, Aswin Hari, Tie Xia, Yan Shi. Strong adhesion by regulatory T cells induces dendritic cell cytoskeletal polarization and contact-dependent lethargy. Journal of Experimental Medicine, 214:327, 2017.
- 20. Hai Qi#. T follicular helper cells in space-time. Nature Reviews Immunology, 16:612-625, 2016.
- 21. Ran He*, Shiyue Hou*, Cheng Liu*, Anli Zhang, Qiang Bai, Miao Han, Yu Yang, Gang Wei, Ting Shen, Xinxin Yang, Lifan Xu, Xiangyu Chen, Yaxing Hao, Chuhong Zhu, Juanjuan Ou, Houjie Liang, Ting Ni, Xiaoyan Zhang, Xinyuan Zhou, Jianqing Xu#, Hai Qi#, Yuzhang Wu# and Lilin Ye#. Follicular CXCR5-expressing CD8 T cells curtail chronic viral infection. Nature, 537:412-428, (2016).
- 22. Peng Wang, Chang-ming Shih, Hai Qi#, Yue-heng Lan#. A stochastic model of the germinal center integrating local antigen competition, individualistic T-B interactions and BCR signaling. Journal of Immunology, 197:1169-1182, 2016 (July 15, doi:10.4049/jimmunol.1600411).
- 23. Shan Tang, Zhengpeng Wan, Yiren Gao, Ji-Shen Zheng, Jing Wang, Yan-Yan Si, Xin Chen, Hai Qi, Lei Liu, Wanli Liu. Total chemical synthesis of photoactivatable proteins for light-controlled manipulation of antigen–antibody interactions. Chemical Science (Jan 2016, doi:10.1039/C5SC03404C).
- 24. Xiangjun Chen, Weiling Pan, Yinqiang Sui, Hua Li, Xiaoshan Shi, Xingdong Guo, Hai Qi, Chenqi Xu, and Wanli Liu. Acidic phospholipids govern the enhanced activation of IgG-B cell receptor. Nature Communications 6:8552, 2015 (Oct 6, doi: 10.1038/ncomms9552).
- 25. Xin Chen*#, Weiwei Ma*, Tingxin Zhang, Longyan Wu, and Hai Qi#. Phenotypic Tfh development promoted by CXCR5-controlled re-localization and IL-6 from radiation-resistant cells. Protein & Cell 6:825-832, 2015 (Sept 24, 2015 Epub ahead of print, doi:10.1007/s13238-015-0210-0).
- 26. Weiwei Ma*#, Ruozhu Zhao*, Runqing Yang, Bo Liu, Xin Chen, Longyan Wu, and Hai Qi#. Nuclear receptors of the NR4A family are not required for the development and function of follicular T helper cells. International Immunopharmacology 28:841-845, 2015 (April 18, 2015 Epub ahead of print, doi:10.1016/j.intimp.2015.04.012).
- 27. Xin Chen*, Shan Tang*, Ji-Shen Zheng*, Ruozhu Zhao, Zhi-Peng Wang, Wen Shao, Hao-Nan Chang, Jing-Yuan Cheng, Hui Zhao, Lei Liu#, and Hai Qi#. Chemical synthesis of a two-photon-activatable chemokine and photon-guided lymphocyte migration in vivo. Nature Communications 6:7220, 2015 (May 26, doi: 10.1038/ncomms8220).
- 28. Dan Liu*, Heping Xu*, Changming Shih, Zurong Wan, Xiaopeng Ma, Weiwei Ma, Dan Luo, and Hai Qi#. T-B-cell entanglement and ICOSL-driven feed-forward regulation of germinal centre reaction. Nature, 517:214-218, 2015 (Oct 15, 2014 Epub ahead of print, doi:10.1038/nature13803).
- 29. Coco Chu, Yifeng Wang, Xu Zhang, Xinya Ni, Junxia Cao, Wan Xu, Zhongjun Dong, Pengfei Yuan, Wensheng Wei, Yuanwu Ma, Lianfeng Zhang, Longyan Wu, and Hai Qi#. SAP-regulated T cell-APC adhesion and ligation-dependent and -independent Ly108-CD3z interactions. Journal of Immunology, 193:3860-3871, 2014 (Sep 12, Epub ahead of print, doi:10.4049/jimmunol.1401660)
30. 30. Hai Qi#, Xin Chen, Coco Chu, Dan Liu, Weiwei Ma, Yifeng Wang, Longyan Wu, Hu Yan, and Jiacong Yan. Tfh cell differentiation and their function in promoting B-cell responses. Advances in Experimental Medicine and Biology, 841:153-180, 2014
- 31. Hai Qi#, Wolfgang Kastenmuller# and Ronald N Germain#. Spatio-temporal basis of innate and adaptive immunity in secondary lymphoid tissue. Annual Review of Cell and Developmental Biology, 30:141-167, 2014 (Aug 8, Epub ahead of print, doi: 10.1146/annurev-cellbio-100913-013254)
- 32. Hai Qi#, Dan Liu, Weiwei Ma, Yifeng Wang, Hu Yan. Bcl-6 controlled TFH polarization and memory: the known unknowns. Current Opinion in Immunology, 28:34-41, 2014
- 33. Junjiao Yang, Yuan Zhang, Pengfei Yuan, Yuexin Zhou, Changzu Cai, Qingpeng Ren, Dingqiao Wen, Coco Chu, Hai Qi, and Wensheng Wei. Complete decoding of TAL effectors for DNA recognition. Cell Research, 24:628-631, 2014
- 34. Xindong Liu, Xin Chen, Bo Zhong, Yaoqi Alan Wang, Xiaohu Wang, Fuliang Chu, RozaNurieva, Xiaowei Yan, Ping Chen, Laurens van der Flier, Hiroko Nakatsukasa, SattvaNeelapu, Wanjun Chen, Hans Clevers, Qiang Tian, Hai Qi, Lai Wei, and Chen Dong. Transcription factor Achaete-Scute homologue 2 initiates T follicular helper cell development. Nature, 507:513-518, 2014
- 35. Longyan Wu, Peiwen Lu, Weiwei Ma, Coco Chu, Heping Xu, and Hai Qi#. Identification of a new isoform of the murine Sh2d1a gene and its functional implications. Science China Life Sciences 57: 1–7, 2014.
- 36. Hai Qi#, Xin Chen, CoCo Chu, Peiwen Lu, Heping Xu, and Jiacong Yan. Follicular T-helper cells: controlled localization and cellular interactions. Immunology & Cell Biology, 92:28-33, 2014.
- 37. Seung Goo Kang*, Wen-Hsien Liu*, Peiwen Lu*, Hyun Yong Jin, Hyung W Lim, Jovan Shepherd, Daniel Fremgen, Eric Verdin, Michael B A Oldstone, Hai Qi, John R Teijaro, and Changchun Xiao. MiR-17~92 family microRNAs are critical regulators of T Follicular helper cell differentiation. Nature Immunology 14:849-57, 2013. (* co-first authors)
- 38. Heping Xu, Xuanying Li, Dan Liu, Jianfu Li, Xu Zhang, Xin Chen, Shiyue Hou, Lixia Peng, Chenguang Xu, Wanli Liu, Lianfeng Zhang, and Hai Qi#. Follicular T-helper cell recruitment governed by bystander B cells and ICOS-driven motility. Nature 496:523-527, 2013.
- 39. Hai Qi#. From SAP-less T cells to helpless B cells and back: dynamic T-B interactions in germinal center development. Immunological Reviews 247:24-35, 2012.
- 40. Roza I. Nurieva, Andrew Podd, Yuhong Chen, Andrei M. Alekseev, Mei Yu, Xiaopeng Qi, Hua Huang, Renren Wen, Junmei Wang, Haiyan S. Li, Stephanie S. Watowich, Hai Qi, Chen Dong, and Demin Wang. STAT5 negatively regulates T follicular helper (Tfh) cell generation and function. Journal of Biological Chemistry 287:11234-9, 2012.
- 41. Yin Liu, Natalya V. Belkina, Chung Park, Raj Nambiar, Scott M. Loughhead, GenaroPatino-Lopez, Khadija Ben-Aissa, Jian-Jiang Hao, Michael J. Kruhlak, Hai Qi, Ulrich H. von Andrian, John H. Kehrl, Matthew J. Tyska, and Stephen Shaw. Constitutively active ezrin increases membrane tension, slows migration, and impedes endothelial transmigration of lymphocytes in vivo in mice. Blood 119:445-453, 2012.
- 42. Jennifer L. Cannons, Hai Qi, Kristina T. Lu, Mala Dutta, Julio Gomez-Rodriguez, Jun Cheng, Edward K. Wakeland, Ronald N. Germain, and Pamela L. Schwartzberg. Optimal Germinal Center Responses Require A Multistage T Cell: B Cell Adhesion Process Involving Integrins, SLAM-Associated Protein, and CD84. Immunity 32:253, 2010.
- 43. Frederick Klauschen, Masaru Ishii, Hai Qi, Marc Bajénoff, Jackson G Egen, Ronald N Germain, and Martin Meier-Schellersheim. Quantifying cellular interaction dynamics in 3D fluorescence microscopy data. Nature Protocols 4:1305-11, 2009.
- 44. Frederick Klauschen, Hai Qi, Jackson G Egen, Ronald N Germain, and Martin Meier-Schellersheim. Computational reconstruction of cell and tissue surfaces for modeling and data analysis. Nature Protocols 4:1006-1012, 2009.
- 45. Pamela L. Schwartzberg, Kristen L. Mueller, Hai Qi, and Jennifer L. Cannons. SLAM receptors and SAP influence lymphocyte interactions, development and function. Nature Reviews Immunology 9:39-46, 2009.
- 46. Hai Qi*, Jennifer L. Cannons*, Frederick Klauschen, Pamela L. Schwartzberg, and Ronald N. Germain. SAP-controlled T-B cell interactions underlie germinal centre formation. Nature 455:764-769, 2008. (* co-first authors)
- 47. Ronald N. Germain, Marc Bajénoff, Flora Castellino, Marcello Chieppa, Jackson G. Egen, Alex Y. C. Huang, Masaru Ishii, Lily Y. Koo, and Hai Qi. Making friends in out-of-the-way places: how cells of the immune system get together and how they conduct their business as revealed by intravital imaging. Immunological Reviews 221:163-181, 2008.
- 48. Marc Bajénoff, Jackson G. Egen, Hai Qi, Alex Y.C. Huang, Flora Castellino, and Ronald N. Germain. Highways, Byways, and Breadcrumbs: Directing Lymphocyte Traffic in the Lymph Node. Trends in Immunology 28:346-352, 2007.
- 49. Hai Qi, Jackson G. Egen, Alex Y. C. Huang, and Ronald N. Germain. Extrafollicular activation of lymph node B cells by antigen-bearing dendritic cells. Science 312:1672-1676, 2006.
- 50. Marc Bajénoff , Béatrice Breart, Alex Y.C. Huang, Hai Qi, Julie Cazareth, Veronique M. Braud, and Ronald N. Germain, Nicolas Glaichenhaus. NK cell behavior in lymph nodes revealed by static and real-time imaging. Journal of Experimental Medicine 203:619-631, 2006.
- 51. Ronald N. Germain, Flora Castellino, Marcello Chieppa, Jackson G. Egen, Alex Y.C. Huang, Lily Y. Koo, and Hai Qi. An extended vision for dynamic high-resolution intravital immune imaging. Seminars in Immunology 17:431-441, 2005.
- 52. Alex Y.C. Huang, Hai Qi, and Ronald N. Germain. Illuminating the landscape of in vivo immunity: insights from dynamic in situ imaging of secondary lymphoid tissues. Immunity 21:331-339, 2004.
- 53. Hai Qi, JiaxiangJi, Nanchaya Wanasen and Lynn Soong. Enhanced replication of Leishmania amazonensis amastigotes in interferon-g-stimulated murine macrophages: implications for the pathogenesis of cutaneous leishmaniasis. Infection and Immunity 72:988-995, 2004.
- 54. Timothy L. Denning, Hai Qi, Rolf König, Kevin G. Scott, Makoto Naganuma, and Peter B. Ernst. CD4+ Th cells resembling regulatory T cells that inhibit chronic colitis differentiate in the absence of interactions between CD4 and Class II MHC. Journal of Immunology 171:2279-2286, 2003.
- 55. Hai Qi, Timothy L. Denning, and Lynn Soong. Differential induction of IL-10 and IL-12 in dendritic cells by microbial Toll-Like Receptor activators and the skewing of T cell cytokine profiles. Infection and Immunity 71:3337-3342, 2003.
- 56. Jiaxiang Ji, Jiaren Sun, Hai Qi, and Lynn Soong. Analysis of T helper cell responses during infection with Leishmania amazonensis. American Journal of Tropical Medicine & Hygiene 66:338-345, 2002.
- 57. S. Wesley Long, Xiao-Feng Zhang, Hai Qi, Steven Standaert, David H. Walker, and Xue-Jie Yu. Antigenic variation of Ehrlichia chaffeensis resulting from differential expression of the 28-kilodalton protein gene family. Infection and Immunity 70:1824-1831, 2002.
- 58. Hai Qi, Vsevolod Popov, and Lynn Soong. Leishmania amazonensis-dendritic cell interactions in vitro and the priming of parasite-specific CD4+ T cells in vivo. Journal of Immunology 167:4534-4542, 2001.