董教授主要致力于免疫学的研究,重点探讨免疫耐受和免疫应答的分子调控机制,以理解自身免疫和过敏疾病的发病机理,并探索新型肿瘤免疫治疗.董晨教授是 Th17 细胞分化、调节和功能研究领域的奠基者和研究权威之一,并在 Tfh 和 Tfr 细胞的发现和研究中,做出了开创性贡献。他的主要研究领域包括:

1. T细胞分化和功能调控;

2. 细胞因子在炎症的功能及其机制;

3. 免疫耐受与肿瘤免疫治疗.

ORCID：0000-0002-0084-9130

Researcher ID：B-3181-2009

代表性论著

1、Ni, L., Ye, F., Cheng, M.-L., Feng, Y., Deng, Y.-Q., Zhao, H., Wei, P., Ge, J., Gou, M., Li, X., Sun, L., Cao, T., Wang, P., Zhou, C., Zhang, R., Liang, P., Guo, H., Wang, X., Qin, C.-F., Chen, F. and Dong, C. Characterization of anti-viral immunity in recovered individuals infected by SARS-CoV-2. (2020) Immunity. In press.

2、Wang, X., Ni, L., Wan, S., Zhao, X., Ding, X., Dejean, A. and Dong, C. Febrile Temperature Critically Controls the Differentiation and Pathogenicity of T Helper 17 Cells. (2020) Immunity. 52:328-341.

3、Xu, W., Zhao, X., Wang, X., Feng, H., Gou, M., Jin, W., Wang, X., Liu, X. and Dong, C. The transcription factor Tox2 drives T follicular helper cell development via regulating chromatin accessibility. (2019) Immunity. 51:826-839.

4、Su, Y., Huang, J., Zhao, X., Lu, H., Wang, W., Yang, X. O., Shi, Y., Wang, X., Lai, Y. and Dong, C.  (2019) Interleukin-17 receptor D constitutes an alternative receptor for interleukin-17A important in psoriasis-like skin inflammation. (2019) Science Immunology. 4:36.

5、Liu, X.,Wang, Y., Lu, H., Li, J., Yan, X., Xiao, M., Hao, J., Hoang, O. N., Khong, H., Chen, T., Huang, R., Wu, J., Zhao, Q., Wu, Q., Xu, S., Wang, X., Jin, W., Yu, S., Wang, Y., Wei, L., Wang, A., Zhong, B., Ni, L., Liu, X., Nurieva, R., Ye, L., Tian, Q., Bian, X.-W. and Dong, C. Genome-wide analysis identifies Nr4a1 as a key mediator of T cell dysfunction. (2019) Nature. 567:525-529.

6、 Xu, M., Lu, H., Wu, Y., Liu, K., Shi, Y., An, H., Zhang, J., Wang, X., Lai, Y. and Dong, C. An IL-25-mediated autoregulatory circuit in keratinocytes plays a pivotal role in psoriatic skin inflammation. (2018) Immunity. 48:787-798.

7、Li, J., Lee, Y., Li, Y., Jiang, Y., Lu, H., Zang, W., Zhao, X., Liu, L., Chen, Y., Tan, H., Yang, Z., Zhang, M. Q., Mak, T. W., Ni, L. and Dong, C. Co-inhibitory molecule B7 superfamily member 1 expressed by tumor-infiltrating myeloid cells induces dysfunction of anti-tumor CD8+ T cells. (2018) Immunity. 48:773-786.

8、Jiang, Y., Liu, Y., Lu, H., Sun, S.-C., Jin, W., Wang, X. and Dong, C. Epigenetic activation during T helper 17 (Th17) cell differentiation is mediated by Tripartite motif containing 28. (2018) Nature Communications. 9:1424.

9、Fu, W., Liu, X., Lin, X., Feng, H., Sun, L., Li, S., Chen, H., Tang, H., Lu, L., Jin, W. and Dong, C. Deficiency in T follicular regulatory cells promotes autoimmunity. (2018) Journal of Experimental Medicine. 215:815-825.