Email: liulab @ mail.tsinghua.edu.cn
The Laboratory of Wanli Liu
Wanli Liu, Ph.D.
Principal Investigator, Distinguished Young Scholar of National Natural Science Foundation of China, Distinguished Professor/Scholar of Ministry of Education, Youth Science and technology innovation leader of Ministry of Science and Technology, China.
Wanli Liu is a tenured professor and Ph.D supervisor of the School of Life Sciences of Tsinghua University, and a researcher at the Institute of Immunology of Tsinghua University and the Center for Life Sciences. Supported by the National Science Fund for Distinguished Youth, Changjiang Scholars Distinguished Professor of the Ministry of Education, and Science and Technology Innovation Leaders of the Ministry of Science and Technology. Focus on the fundamental immunology research of B lymphocytes, and devote to the integration of interdisciplinary platforms to study the pathogenic mechanism involving B cell immune recognition, immune activation and related immune diseases. Multiple corresponding paper (including co-corresponding) was published in the aspect of the regulation of lymphocyte activation and related diseases (Science, J Exp Med, Cell Research, Leukemia and eLife), new pathways of lipid metabolism network regulating lymphocyte activation (Cell, PLOS Biology, Science Immunology, Cell Reports and Nature Communications), the new mechanism of antigen receptor microclusters regulating lymphocyte activation (Science Advances, PNAS and eLife 2019b) and the new model of mechanical force sensing regulating B cell activation (J Cell Biol, Science Signaling and eLife15/17) and other research directions. Related results were selected as part of the top ten medical science and technology news in China in 2018. Won the China Youth Science and Technology Award, WuXi AppTec Life Chemistry Outstanding Achievement Award, Tan Jiazhen Life Science Innovation Award, Shulan Medical Youth Award and other awards. Invited to hold lectures at domestic and foreign academic conferences (Keystone B cell conference in 2022, Antigen Receptor Signal Transduction Biennial Conference in 2022, 2018 and 2016 EMBO Conference, 2018 American Rheumatism Annual Conference, etc.). Served as an editorial board member of the Chinese Journal of Immunology, Rheumatology & Autoimmunity, Frontiers in Immunology; reviewed scientific research projects for NSFC, MOST, NIH, UK Wellcome Trust Foundation, Dutch Research Council, etc.; by 2021, a total of 6 post-doctoral fellows and 11 graduated PhDs have been trained , 6 masters graduated.
Medical Science Building, RM-A103
Tsinghua University, Beijing, China, 100084
2011.12 – present , Principal Investigator, School of Life Sciences, Institute for Immunology, Tsinghua University
2007 – 2011, Postdoc, NIAID, NIH, USA
2005 – 2007, Postdoc, Dept. of Microbiology/Immunology, UCSF, USA
2001 – 2005, Ph.D, Dept. of Biological Science and Biotechnology, Tsinghua University
1997 – 2001, Bachelor, School of Biology, China Agriculture University
Recognitions and Awards
2012 Outstanding Talents of the New Century, Chinese Ministry of Education
2014 Awardee of Excellent Young Teachers from Dr. Henry Fok Education Foundation
2014 Excellent Young Scholars, National Natural Science Funds of China
Postdoctoral fellow of Wanli Liu’s lab~ Sport girl who loves experiments.
From Handan, Hebei. Enter Tsinghua University since 2015.9 till now.
Xingyu Ji was PhD candidate graduated from Wuhan University and now major in immunology since 2016. His work focus on early signaling of lymphocytes activation and relevant clinical transformation.
Ph.D Candidate, School of life science, Tsinghua University.
Color my life with the chaos of trouble.
We're all playing the same game,waiting on our loan.
Grade 2018, from Lu'an, Anhui Province.
From Zhuzhou, Hunan province, still studying.
Qinghui Duan (2020 class)
Shandong University, B.S.(2016-2020)
Center for Life Sciences, Tsinghua University, (2020- )
Research Areas: Molecular immunology, cell biology
Wenbo Sun, graduated from Shandong University with a bachelor's degree. In September 2019, he was admitted to Tsinghua University through the CLS program and studied for a doctorate in Wanli Liu's laboratory. His research focuses on the production of broad-spectrum neutralizing antibodies and the mechanism of antibody affinity maturation.
Comes from Jinan, Shandong province. She graduated from Shandong Normal University with a bachelor's degree in biological science. She graduated from Peking Union Medical College with a master's degree in biochemistry and molecular biology. In 2020, she entered Tsinghua University through the PTN program to study for a doctorate, and was assigned to Wanli Liu's lab. Her current research interest is tumor antigen specific antibody response.
We combine immunological and biochemical experimental approaches with cutting-edge high resolution high speed live cell and molecule imaging techniques to investigate the function of lymphocyte cells. We are working on the studies of: (1) Lymphocytes activation and regulation; (2) Immune-diseases induced by abnormal lymphocyte activation; (3) Immunological memory; (4) Mechanosensing biology of lymphocytes; (5) Immune-evasion; (6) Next generation vaccines based on the new understanding of lymphocyte activation and function.
Representative Research articles and Reviews (*, corresponding author):
 Jing Chen#, Xiaochen Zhang#, Liping Li#, Xianqiang Ma, Chunxiao Yang, Zhaodi Liu, Chenyang Li, Maria J. Fernandez-Cabezudo, Basel K. al-Ramadi, Chuan Wu, Weishan Huang, Yong Zhang*, Yonghui Zhang*, Wanli Liu*. Farnesyl pyrophosphate is a new danger signal inducing acute cell death. PLoS Biology. 2021, 19:e3001134. doi: 10.1371/journal.pbio.3001134.
 Xingwang Zhao#, Hengyi Xie#, Meng Zhao#, Asma Ahsan, Xinxin Li, Fei Wang, Junyang Yi, Zhiyong Yang, Chuan Wu, Indu Raman, Quan-Zhen Li*, Tae Jin Kim*, Wanli Liu*. Fc receptor-like 1 intrinsically recruits c-Abl to enhance B cell activation and function. Science Advances. 2019, 5, eaaw0315, DOI: 10.1126/sciadv.aaw0315
 Zhixun Shen#, Sichen Liu#, Xinxin Li#, Zhengpeng Wan, Youxiang Mao, Chunlai Chen, Wanli Liu*. Conformational change within the extracellular domain of B cell receptor in B cell activation upon antigen binding. eLife. 2019, 8, doi: 10.7554/eLife.42271.
 Chenguang Xu#, Yan Fang#, Zhiyong Yang, Yukai Jing, Yonghui Zhang, Chaohong Liu*, Wanli Liu*. MARCKS regulates tonic and chronic active B cell receptor signaling. Leukemia. 2019, 33:710-729.
 Xiangjun Chen, Xiaolin Sun#, Wei Yang#, Bing Yang#, Xiaozhen Zhao, Shuting Chen1, Lili He, Hui Chen, Changmei Yang, Le Xiao, Zai Chang, Jianping Guo, Jing He, Fuping Zhang, Fang Zheng, Zhibin Hu, Zhiyong Yang, Jizhong Lou, Wenjie Zheng, Hai Qi, Chenqi Xu, Hong Zhang, Hongying Shan, Xu-jie Zhou, Qingwen Wang, Yi Shi, Luhua Lai, Zhanguo Li *, Wanli Liu*. An autoimmune disease variant of IgG1 modulates B-cell activation and differentiation. Science. 2018, 362:700-705.
Copyright © 2017 Institute for Immunology Tsinghua University
Contact Address: Room D302, Medical Science Building, Tsinghua University, Beijing 100084, China
Tel: (86) 10-62776420 Fax: (86) 10-62776420