Email: Ustcdzj @ yahoo.com
The Laboratory of Zhongjun Dong
Zhongjun Dong, Ph.D.
2000-2003 Master, Shandong Academy of Medical Sciences, China
2003-2006 Ph.D., University of Science and Technology of China Mentor: Zhigang Tian, M.D., Ph.D.
2006-2011 Postdoctoral Fellow, Clinical Research Institute of Montreal, Canada (Advisor: Andre Veillette, M.D.)
2011-present Assistant Professor, School of Medicine, Tsinghua University, China
2014-present Assistant Professor/Principal Investigator, Institute for Immunology, Tsinghua University, China
Recognitions and Awards
2017 The National Science Fund for Distinguished Young Scholars
2012-2016 Jansen-Tsinghua Fellowship
2013 The National Science Fund for Excellent Young Scholars
2008-2011 Canadian Institutes of Health Research (CIHR) Fellowship, CIHR, Canada
2007 Angelo Pizzagalli Postdoctoral Fellowship, Institut de Recherches cliniques de Montreal
2005 Presidential Scholarship of Chinese Academy of Sciences (CAS)
Junming He, Ph.D.
Junming He joined Dong’ lab as a postdoc in 2019, whose interest is NK cell development.
Dan Li, Ph.D.
Dan Li got her Ph.D. degree in Tsinghua University and joined Zhongjun Dong’s laboratory for post-doctoral research. Her research mainly focuses on Tumor immunology.
Jian Wang, Ph.D.
After graduating from Fudan University, Jian Wang joined in tumor immunology lab as a postdoc in 2020. He likes all guys and current works here and looks forward to the future.
Yajun Leng, Ph.D.
Yajun Leng joined Dong’ lab as a postdoc in September 2020 and obtained her Doctor of Cell Biology at China Agricultural University in June 2021. Her research focuses on tumor immunotherapy.
Lingna Zhao, Ph.D.
Lingna Zhao got her Ph.D. degree from Academy of Military Sciences PLA China and joined in Dong Zhongjun’s lab in January, 2021. Her research focuses on NK cell biology.
Haoyan Yang joined Dong's laboratory as a Ph.D student in 2016，with a bachelor's degree from Capital Medical University. She worked on projects about NK cells education successively during doctoral training.
Ph.D student (From 2016) in School of Medicine.
Received bachelor's degree from Minzu University of China.
Research focus: humoral immunity.
Jun Zhao joined Dong's laboratory as a Ph.D student in 2016.
PhD student (since 2016) in Institute for Immunology of Tsinghua University. She received her Bachlor's Degree from Jilin University. Her research focuses on the role of SLAM family members in anti- hematopoietic tumor immunity.
Yuhe Quan joined Dong's laboratory as a Ph.D student in 2017，with a bachelor's degree from Shandong University. Her work focuses on post-transcriptional regulation of NK cell development.
Joined Dong's laboratory as a Ph.D student in 2017，with a bachelor's degree from Peking University.
PhD student (since 2019). He obtained his Master's degree from Jinan University. His research focuses on lymphocyte development and function.
Chengyuan Lu, Ph.D student (From2019) in PTN. His research interest is immune tolerance and tumor immnuotherapy.
Donglin Chen is a PhD student who joined the Dong lab at 2020. He focuses on tumor immunology, trying to find a new way to fight against ancient evil of humankind——cancer.
Zihao Zou is a student of eight-year MD program, joining Dong’s lab in 2020 for the two-year basic medicine research training. Zou’s main project focus on the clinical application of NK cells and the development of dendritic cells.
Temporal and spatial regulation of NK cell functional competence
Regulation of NK cell activation and NK-T cell development by SLAM family receptors and SAP- related family adaptors
Regulation of NK cell development and activation by PI3K-mTOR
1.Chen S, Li Z, Cai C, Liu GW, Wang Y, Blonska M, Dan Li D, Du J, Lin X, Yang M, and Dong Z*. Dissection of SAP-dependent and SAP-independent SLAM Family Signaling in NKT Cell Development and Humoral Immunity, Journal Experimental Medicine. 2017 Feb;214(2):475-489.
2.Chen S, Yang M, Du J, Li D, Li ZH, Cai C, Ma Y, Zhang Y, Tian Z*, and Dong Z*. The self-specific activation receptor SLAM family is critical to NK cell education. Immunity. 2016, 45(2): 292-304.
3.Yang M, Chen S, Du J, He J, Wang Y, Zehua, Li Z, Liu G, Peng W, Zeng X, Li D, Xu P, Guo W, Chang Z, Wang S, Tian Z and Dong Z*. NK cell development requires Tsc1-dependent negative regulation of IL-15-trgiggered mTORC1 activation. Nature Communications. 2016 Sep 7;7:12730
4.Du J, Yang MX, Chen SS, Li D, Chang Z, and Dong Z* PDK1 promotes tumor growth and metastasis in a spontaneous breast cancer model. Oncogene, 2016;35(25):3314-23.
5.Yang M, Li D, Chang Z, Yang Z, Tian Z, Dong Z*. PDK1 orchestrates early NK cell development through induction of E4BP4 expression and maintenance of IL-15 responsiveness. Journal Experimental Medicine. 2015 212(2):253-65.
6. Dong Z*, Davidson D, Pérez-Quintero L.A, Kurosaki T, Swat W, and Veillette A. The Adaptor SAP Controls NK Cell Activation by Regulating the Enzymes Vav-1 and SHIP-1 and by Enhancing Conjugates with Target Cells. Immunity, 2012; 36(6):974-85.
7.Dong Z, Veillette A. How do SAP family deficiencies compromise immunity? Trends in Immunology; 2010 Aug;31(8):295-302
8. Dong Z, Cruz-Munoz ME, Zhong M, Chen R, Latour S and Veillette A. Essential role of SAP family adaptors in natural killer cell surveillance of hematopoietic cells. Nature Immunology; 10(9); (2009):973-80.
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Contact Address: Room D302, Medical Science Building, Tsinghua University, Beijing 100084, China
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