Wenwen Zeng

Wenwen Zeng

Phone: 86-10-62782861

Email: wenwenzeng@tsinghua.edu.cn

  • Principal Investigator
  • Research Fields
  • Publications
  • Research Team


Professional Experience

1998-2002 B.S., Biological Sciences, Tsinghua University, China

2003-2009 Ph.D., The University of Texas Southwestern Medical Center, USA (Mentor: Zhijian "James" Chen, Ph.D.)

2009-2011 Postdoctoral Research Fellow, Department of Discovery Immunology, Genentech Inc., USA  (Mentor: Harinder Singh, Ph.D.)

2011-2014 Postdoctoral Fellow, Howard Hughes Medical Institute, Laboratory of Molecular Genetics, The Rockefeller University, USA (Mentor: Jeffrey M. Friedman, Ph.D.)

2015-present Assistant Professor/Principal Investigator, School of Medicine & Institute for Immunology, Tsinghua, University, China


Recognitions and Awards

2016 Outstanding Young Scholar Award, Qiu-Shi Science & Technologies Foundation

2018 Young Investigator Award, Lipid Metabolism and Bioenergetics Subsociety of the Biophysical Society of China


Inflammation and diseases


Metabolic homeostasis and disorders


Neuronal regulation of tissue homeostasis


ORCID: 0000-0001-8544-3318


ResearcherID: D-7276-2017


Selected Publications:


  1. Hu Z. and Zeng W. Splenic leukocytes get the nerves up for myelopoiesis. Immunity, 2018 Jul 17; 49(1):1-3.
  2. Cao Y*, Wang H*, Wang Q, Hang X, Zeng W. Three-Dimensional Volume Fluorescence-Imaging of Vascular Plasticity in Adipose Tissues. Molecular Metabolism, 2018 Aug; 14:71-81. (* first-authors contributed equally)
  3. Wang Q*, Zhang S*, Liu T*, Wang H, Liu K, Wang Q, Zeng W. Sarm1/Myd88-5 Regulates Neuronal Intrinsic Immune Response to Traumatic Axonal Injuries. Cell Reports, 2018 Apr 17; 23(3): 716-724. (* first-authors contributed equally)
  4. Cao Y, Wang H, Zeng W. Whole-Tissue 3D Imaging Reveals Intra-Adipose Sympathetic Plasticity Regulated by NGF-TrkA Signal in Cold-Induced Beiging. Protein & Cell, 2018 Jun; 9(6): 527-539.
  5. Jiang H*, Ding X*, Cao Y, Wang H, Zeng W. Dense intra-Adipose sympathetic arborizations are essential for cold-induced beiging of mouse white adipose tissues.  Cell Metabolism. 2017 Oct 3; 26(4): 686-692.e3. (* first-authors contributed equally)
  6. Zhang S, Li N, Zeng W, Gao N, Yang M. Cryo-EM structures of the mammalian endo-lysosomal TRPML1 channel elucidate the combined regulation mechanism. Protein & Cell, 2017 Nov 21;8(11): 834-847.
  7. Zeng W*, Pirzgalska RM*, Pereira MM, Kubasova N, Barateiro A, Seixas E, Lu YH, Kozlova A, Voss H, Martins GG, Friedman JM, Domingos AI. Sympathetic Neuro-adipose Connections Mediate Leptin-Driven Lipolysis. Cell. 2015 Sep 24; 163(1): 84-94. (* first-authors contributed equally)
  8. Peng Y*, Zeng W*, Ye H, Han KH, Dharmarajan V, Novick S, Wilson IA, Griffin PR, Friedman JM, Lerner RA. A General Method for Insertion of Functional Proteins within Proteins via Combinatorial Selection of Permissive Junctions. Chem Biol. 2015 Aug 20; 22(8): 1134-43. (* first-authors contributed equally)
  9. Zeng W*, Lu YH*, Lee J, Friedman JM. Reanalysis of parabiosis of obesity mutants in the age of leptin. Proc Natl Acad Sci U S A. 2015 Jul 21; 112(29):E3874-82. (* first-authors contributed equally)
  10. Glasmacher E*, Agrawal S*, Chang AB*, Murphy TL*, Zeng W*, Vander Lugt B, Khan AA, Ciofani M, Spooner CJ, Rutz S, Hackney J, Nurieva R, Escalante CR, Ouyang W, Littman DR, Murphy KM, Singh H. A genomic regulatory element that directs assembly and function of immune-specific AP-1-IRF complexes. Science. 2012 Nov 16; 338(6109): 975-80. (* first-authors contributed equally)
  11. Rutz S, Noubade R, Eidenschenk C, Ota N, Zeng W, Zheng Y, Hackney J, Ding J, Singh H, Ouyang W. Transcription factor c-Maf mediates the TGF--dependent suppression of IL-22 production in T(H)17 cells. Nat Immunol. 2011 Oct 16; 12(12): 1238-45, 2011
  12. Zeng W*, Sun L*, Jiang X, Chen X, Hou F, Adhikari A, Xu M, Chen ZJ. Reconstitution of the RIG-I pathway reveals a signaling role of unanchored polyubiquitin chains in innate immunity. Cell. 2010 Apr 16; 141(2): 315-30. (* first-authors contributed equally)
  13. Zeng W, Xu M, Liu S, Sun L, Chen ZJ. Key role of Ubc5 and lysine-63 polyubiquitination in viral activation of IRF3. Mol Cell. 2009 Oct 23; 36(2): 315-25.
  14. Zeng W, Chen ZJ. MITAgating viral infection. Immunity. 2008 Oct 17; 29(4): 513-5.
  15. Xu M, Skaug B, Zeng W, Chen ZJ. A ubiquitin replacement strategy in human cells reveals distinct mechanisms of IKK activation by TNFalpha and IL-1beta. Mol Cell. 2009 Oct 23; 36(2): 302-14
  16. Xia ZP, Sun L, Chen X, Pineda G, Jiang X, Adhikari A, Zeng W, Chen ZJ. Direct activation of protein kinases by unanchored polyubiquitin chains. Nature. 2009 Sep 3; 461(7260): 114-9.
  17. Yang M, Xu G, Li S, Sun L, Shi N, Zeng W, Pang H, Zhang W, Rao Z. Crystallization and preliminary crystallographic analysis of the extracellular fragment of FcalphaRI/CD89. Acta Crystallogr D Biol Crystallogr. 2003 59(Pt 12): 2251-3.
  18. Sun ZH, Lai YL, Zeng WW, Zhao D, Ye ZW, Zuo HC, Xie ZP. Mesencephalic progenitors can improve rotational behavior and reconstruct nigrostriatal pathway in PD rats. Acta Neurochir Suppl. 2003 87:175-80.
  19. Sun ZH, Lai YL, Zeng WW, Zhao D, Zuo HC, Xie ZP. Neural stem/progenitor cells survive and differentiate better in PD rats than in normal rats. Acta Neurochir Suppl. 2003 87:169-74.
Research Team Alumni