Chen Dong

Chen Dong

Phone: 86-10-62798095

Email: chendong@tsinghua.edu.cn

2019.7
20
  • Principal Investigator
  • Research Fields
  • Publications
  • Research Team

Professional Experience

1985-1989     Bachelor, Wuhan University, Wuhan, China.   Major: Cell Biology    

1990-1996     Ph.D,  University of Alabama at Birmingham, Cell and Molecular Biology Graduate Program

1997-2000     Postdoctoral Fellow, Section of Immunobiology

                      Yale University School of Medicine. Advisor: Richard A. Flavell, Ph.D

2000-2004     Assistant Professor, Department of Immunology, University of Washington School of Medicine

2004-2008     Associate Professor (tenured), Department of Immunology.

                      University of Texas MD Anderson Cancer Center

2008- 2014    Professor (tenured), Department of Immunology, University of Texas MD Anderson Cancer Center

2008-2013     Director, Center for Inflammation and Cancer,MD Anderson Cancer Center

2010- 2014    Olga Keith and Harry Carothers Wiess Distinguished University  Chair in Cancer Research,

                      MD Anderson Cancer Center

2013-2016     Vice Dean, School of Medicine, Tsinghua University

2014-present  Director, Institute for Immunology, Tsinghua University

2015-present  Vice Director (Tsinghua),

                       Peking University-Tsinghua University Center for Life Sciences, Beijing, China

2016- 2016     Executive Vice Dean, School of Medicine, Tsinghua University

2016- present  Dean, School of Medicine, Tsinghua University

2017                Director, Beijing Key Lab on Immunological Studies on Chronic Diseases

 

Recognitions and Awards

2009 American Association of Immunologists- BD Bioscience Investigator Award

2011 Fellow, American Association for the Advancement of Science

2014, 2015,  2016 Highly Cited Researcher, Thomson Reuters

2016 Keynote speaker, 2016 Keystone Symposium on T Follicular Helper Cells and Germinal Centers

2017 Highly Cited Researcher, Clarivate Analytics

2018 Highly Cited Researcher, Clarivate Analytics2018

2018 Keynote speaker, 45th Annual Meeting of Indian Immunology Society- Immunocon 2018

2018 Plenary Lecture, Korean Association of Immunologists International Meeting 2018

2018 Fountain Valley Investigator of Life Sciences (FViL)

2019 BioLegend William E. Paul Award for Excellence in Cytokine Research


  1.  

 

Immunology and Inflammation

We are interested in studying the cellular and molecular mechanisms underlying immune tolerance and immune responses and hope that our research will lead to new approaches of modulating the immune system in a variety of immune diseases and cancers.

1. T lymphocyte differentiation and function
2. Cytokine function and signaling in inflammation
3. Immune tolerance and tumor immunity.

ORCID: 0000-0002-0084-9130

 

ResearcherID: B-3181-2009

 

Selected Publications

 

1. Liu, X., Chen, X., Zhong, B., Wang, A., Wang, X.,Chu, F., Nurieva, R. I., Yan, X., Chen, P., van der Flier, L. G., Nakatsukasa, H., Neelapu, S. S., Chen,W., Clevers, H., Tian, Q., Qi, H., Wei, L. and Dong C. Transcription factor Achaete-Scute homologue 2 initiates T follicular helper cell development. (2014) Nature. 507: 513–518.

 

2. Chang, S. H., Mirabolfathinejad, S. G., Katta, H., Cumpian, A. M., Gong, L., Caetano, M. S., Moghaddam, S. J. and Dong, C. T helper 17 cells play a critical pathogenic role in lung cancer. (2014) Proceedings of National Academy of Sciences, USA 111:5664-5669.

 

3. Reynolds, J. M., Lee, Y.-H., Shi, Y., Angkasekwinai, P., Nallaparaju, K. C., Flaherty, S., Chang, S.H., Watarai, H. and Dong, C. Interleukin-17B antagonizes interleukin-25-mediated mucosal inflammation. (2015). Immunity. 42:692-703.

 

4. Ichiyama, K., Chen, T., Wang, X., Yan, X., Kim, B. S., Tanaka, S., Ndiaye-Lobry, D., Deng, Y., Zou, Y., Zheng, P., Tian, Q., Aifantis, I., Wei, L. and Dong,C. The methylcytosine dioxygenase Tet2 promotes DNA demethylation and activation of cytokine gene expression in T cells. (2015) Immunity. 42:613-626.

 

5. Zhang, Y., Nguyen, T., Tang, P., Kennedy, N. J.,Jiao, H., Zhang, M., Reynolds, J. M., Jaeschke A., Martin-Orozco, N., Chung, Y., He, W. M.,Wang, C., Jia, W., Ge, B., Davis, R. J., Flavell, R. A. and Dong, C. Regulation of Adipose Tissue Inflammation and Insulin Resistance by MAPK Phosphatase 5. (2015). Journal of Biological Chemistry. 290:14875-14883.

 

6. Ding, X., Wang, A., Ma, X., Demarque, M., Jin, W., Xin, H., Dejean, A. and Dong, C. Protein SUMOylation is required for regulatory T cell expansion and function. (2016) Cell Reports. 16:1055-1066.

 

7. Liu, X., Lu, H., Chen, T., Nallaparaju, K. C., Yan, X., Tanaka, S., Ichiyama, K., Zhang, X., Zhang, L., Wen, X., Tian, Q., Bian, X., Jin, W., Lai, W. and Dong, C. Genome-wide analysis identifies Bcl6-controlled regulatory networks during T follicular helper (Tfh) cell differentiation. (2016) Cell Reports. 14:1735-1747.

 

8. Giles, D. A., Moreno-Fernandez, M. E., Stankiewicz, T. E., Cappelletti, M., Huppert, S. S., Iwakura, Y., Dong, C., Shanmukhappa, S. K., Divanovic, S. Regulation of Inflammation by IL-17A and IL-17F Modulates Non-Alcoholic Fatty Liver Disease Pathogenesis. (2016) PLoS One 11:e0149783.

 

9. Lee, J. B., Chen, C. Y., Liu, B., Mugge, L., Angkasekwinai, P., Facchinetti, V., Dong, C., Liu, Y. J., Rothenberg, M. E., Hogan, S. P., Finkelman, F. D., Wang, Y. H. IL-25 and CD4+ TH2 cells enhance type 2 innate lymphoid cell-derived IL-13 production, which promotes IgE-mediated experimental food allergy. (2016) Journal of Allergy and Clinical Immunology. 137:1216-1225.

 

10. Ichiyama, K., Gonzalez-Martin, A., Kim, B.-S., Jin, H. Y., Jin, W., Xu, W., Sabouri-Ghomi, M., Xu, S., Zheng, P., Xiao, C. and Dong, C. The microRNA-183-96-182 cluster promotes T helper 17 cell pathogenicity by negatively regulating transcription factor Foxo1 expression. (2016) Immunity. 44: 1284–1298.

 

11. Huang, J., Meng, S., Hong, S., Lin, X., Jin, W. and Dong, C. IL-17C is required for lethal inflammation during systemic fungal infection. (2016) Cell and Molecular Immunology. 13: 474-483.

 

12. Banuelos, J., Shin, S., Cao, Y., Bochner, B. S., Morales-Nebreda, L., Budinger, G. R., Zhou, L., Li, S., Xin, J., Lingen, M. W., Dong, C., Schleimer, R. P., Lu, N. Z.. BCL-2 protects human and mouse Th17 cells from glucocorticoid-induced apoptosis. (2016) Allergy. 71:640-650.

 

13. Ding, X., Wang, A., Ma, X., Demarque, M., Jin, W., Xin, H., Dejean, A. and Dong, C. Protein SUMOylation is required for regulatory T cell expansion and function. (2016) Cell Reports. 16:1055-1066.

 

14. Sandal, I., Karydis, A., Luo, J., Prislovsky, A., Whittington, K. B., Rosloniec, E. F., Dong, C., Novack, D. V., Mydel, P., Zheng, S. G., Radic, M. Z. and Brand, D. D. Bone loss and aggravated autoimmune arthritis in HLA-DRβ1-bearing humanized mice following oral challenge with Porphyromonas gingivalis. (2016) Arthritis Research and Therapy. 18:249.

 

15. Huang, J., Yuan, Q., Zhu, H., Yin, L., Hong, S., Dong, Z., Jin, W. and Dong, C. Interleukin-17C/IL-17RE augments T cell function in autoimmune hepatitis. (2017) Journal of Immunology. 198:669-680.

 

16. Maturu, P., Jones, D., Ruteshouser, E. C., Hu, Q., Reynolds, J. M., Hicks, J., Putluri, N., Ekmekcioglu, S., Grimm, E. A., Dong, C. and Overwijk, W. W. Role of Cyclooxygenase-2 Pathway in Creating an Immunosuppressive Microenvironment and in Initiation and Progression of Wilms' Tumor. (2017) Neoplasia. 19:237-249.

 

17. Jiang, Z., Chen,J., Du, X., Cheng,H., Wang, X. and Dong, C. IL-25 blockade inhibits metastasis in breast cancer. (2017) Protein and Cell. 8:191-201.

 

18. Zhao, X., Guo, Y., Jiang, C., Chang, Q., Zhang, S., Luo, T., Zhang, B., Jia, X., Hung, M. C., Dong, C. and Lin, X. JNK1 negatively controls antifungal innate immunity by suppressing CD23 expression. (2017) Nature Medicine. 23:337-346.

 

19. Wang, A., Ding, X., Demarque, M., Liu, X., Pan, D., Xin, H., Zhong, B., Wang, X., Dejean, A., Jin, W. and Dong, C. Ubc9 is required for positive selection and late-stage maturation of thymocytes. (2017) Journal of Immunology. 198:3461-3470.

 

20. Lee, Y., Martin-Orozco, N., Zheng, P., Li, J., Zhang, P., Tan, H., Park, H. J., Jeong, M., Chang, S. H., Kim, B.-S., Xiong, W., Zang, W., Guo, L., Liu, Y., Dong, Z., Overwijk, W. W., Hwu, P., Yi, Q, Kwak, L., Yang, Z., Mak, T. W., Radvanyi, L. G., Li, W., Ni, L., Liu, D. and Dong, C. Inhibition of B7-H3 checkpoint limits tumor growth by enhancing cytotoxic lymphocyte function. (2017) Cell Research. 1034-1045.

 

21. Edelblum, K. L., Sharon, G., Singh, G., Odenwald, M. A., Sailer, A., Cao, S., Ravens, S., Thomsen, I., El Bissati, K., McLeod, R., Dong, C., Gurbuxani, S., Prinz, I., Mazmanian, S. K. and Turner, J. R. The microbiome activates CD4 T-cell-mediated immunity to compensate for increased intestinal permeability. (2017) Cellular and Molecular Gastroenterology and Hepatology 4:285-297.

 

22.Liu, H., Cai, Y., Ma, S., Liu, Y., Gong, H., Cheng, Q., Hu, B., Wu, Y., Yu, X., Dong, C., Sun, K. and Wu, D. Adoptively transferred donor IL-17-producing CD4+ T cells augment but IL-17 alleviates acute graft versus host disease. (2017) Cell and Molecular Immunology. In press.

 

23. Xu, T,  Stewart, K. M., Wang, X., Liu, K., Xie, M., Kyu Ryu, J., Li, K., Ma, T., Wang, H., Ni, L., Zhu, S., Cao, N., Zhu, D., Zhang, Y., Akassoglou, K., Dong, C.*, Driggers, E. M.*, Ding, S.* Metabolic control of TH17 and induced Treg cell balance by an epigenetic mechanism. (2017) Nature. In press. (* co-correspondent authors)

 

24.Xu, M., Lu, H., Wu, Y., Liu, K., Shi, Y., An, H., Zhang, J., Wang, X., Lai, Y. and Dong, C. An IL-25-mediated autoregulatory circuit in keratinocytes plays a pivotal role in psoriatic skin inflammation. (2018) Immunity. In press

 

25.Jing Li, Younghee, Lee, Yanjian Li, Yu Jiang, Huiping Lu, Wenjuan Zang, Xiaohong Zhao, Liguo Liu, Yang Chen, Haidong Tan, Zhiying Yang, Michael Q. Zhang, Tak W. Mak, Ling Ni and Chen Dong. Co-inhibitory Molecule B7 Superfamily Member 1 Expressed by Tumor-Infiltrating Myeloid Cells Induces Dysfunction of Anti-tumor CD8+ T Cells. (2018) Immunity. In press

 

26.Jiang, Y., Liu, Y., Lu, H., Sun, S.-C., Jin, W., Wang, X. and Dong, C. Epigenetic activation during T helper 17 (Th17) cell differentiation is mediated by Tripartite motif containing 28. (2018) Nature Communications. In press.

 

27.Weiwei Fu, Xindong Liu, Xiang Lin, Han Feng, Lin Sun, Shuran Li, Hairong Chen, Hong Tang, Liwei Lu, Wei Jin, Chen Dong(*). Deficiency in T follicular regulatory cells promotes autoimmunity. (2018) Journal of Experimental Medicine. 215:815-825

28. Su Y, Huang J, Zhao X, Lu H, Wang W, Yang XO, Shi Y, Wang X, Lai Y, Dong C. Interleukin-17 receptor D constitutes an alternative receptor for interleukin-17A important in psoriasis-like skin inflammation. (2019) Science immunology 4(36).

Invited articles and book chapters

 

1. Lai, Y. and Dong, C. Targeting inflammatory cytokines in the treatment of autoimmune diseases. (2016) (Review). International Immunology. 28:181-188.

 

2. Lai, Y. and Dong, C. Interleukin-17 family (2016) (Review). Encyclopedia of Immunobiology. 2: 534–543. Oxford: Academic Press.

 

3. Ding, X. and Dong, C. Evolution of RAG transposon unveiled. (2016) (Perspective) Science China Life Sciences. 59:968-970

 

4. Li, J., Ni, L. and Dong, C. Immune checkpoint receptors in cancer: redundant by design? (2017) (Review). Current Opinion in Immunology. 45:37-42.

 

5. Ni, L. and Dong, C. New Checkpoints in Cancer Immunotherapy. (2017) (Review) Immunological Reviews. 276:52-65.

 

6. Xu, M. and Dong, C. IL-25 in allergic inflammation. (2017) (Review) Immunological Reviews. 278:185-191.

 

7. Ni, L. and Dong, C. New B7 Family Checkpoints in Human Cancers. (2017) (Review) Molecular Cancer Therapeutics. 16:1203-1211.

 

8. Dong, C. Helper T cells and cancer-associated inflammation - A new direction for immunotherapy? (2017) (Review) Journal of Interferon and Cytokine Research. In press.

9. Ni, L. and Dong, C. Roles of myeloid and lymphoid cells in the pathogenesis of chronic obstructive pulmonary disease. (Review) (2018) Frontiers in Immunology 9:1431.

10. Li, J. and Dong, C. Nobel goes to immune checkpoint-Innovative cancer treatment by immunotherapy. (Commentary) (2018) Science China Life Sciences. 61:1445-1450.

11. Ichiyama, K. and Dong, C. The role of miR-183 cluster in immunity. (Review) (2018) Cancer Letter. 443:108-114

Research Team Alumni