Xiaoyu Hu

Xiaoyu Hu

Phone: 86-10-62795612

Email: xiaoyuhu@tsinghua.edu.cn

2020.6
5
  • Principal Investigator
  • Research Fields
  • Publications
  • Research Team

 

EDUCATION

2004

 

Ph.D., Immunology

Cornell University Weill Graduate School of Medical Sciences, New York, NY

1997

 

B.M., Basic Medical Sciences

Beijing Medical University (currently Peking University Health Science Center), China

 

POSITIONS AND EMPLOYMENTS

2020-present

 

Professor of Immunology

Tsinghua University School of Medicine, Beijing, China

2017-present

 

Associate Professor (with tenure) 

Tsinghua University School of Medicine, Beijing, China

2016-present

 

Vice Chair, Department of Basic Medical Sciences

Tsinghua University School of Medicine, Beijing, China

2014-present

 

Associate Professor (tenure-track)

Tsinghua University School of Medicine (SOM), Beijing, China

2010-2014

 

Assistant Professor of Immunology (tenure-track)

Department of Medicine, Weill Cornell Medicine, New York, NY

2008-2014

 

Assistant Scientist

Research Division, Hospital for Special Surgery, New York, NY

2005-2008

 

Instructor

Research Division, Hospital for Special Surgery, New York, NY

2004-2005

 

Postdoctoral Fellow

Research Division, Hospital for Special Surgery, New York, NY

 

HONORS AND AWARDS

2017

Distinguished Young Investigator Award, National Natural Science Foundation of China

2017

Bayer Investigator Award, Bayer-Tsinghua Joint Research Center

2016

U.K. Royal Society Academy of Medical Sciences-Newton Advanced Fellowship

2015

Janssen Scholar, Janssen-Tsinghua Joint Research Center

2015

Young Investigator Award, National Natural Science Foundation of China

2014

Bayer Investigator Award, Bayer-Tsinghua Joint Research Center

2010

Christina Fleischmann Memorial Award for Young Women Investigator, International Society for Interferon and Cytokine Research

2006

Arthritis Foundation Young Scholar Award

2002

Cornell University Vincent du Vigneaud Award of Excellence

Overall research area: Innate immunity effector functions.

 

Currently, there are four specific research directions in the lab:

1. Molecular mechanisms governing macrophage activation.

2. Biology of tissue-resident macrophages.

3. Regulation of intestinal epithelium barrier functions.

4. The role of monocytes/macrophages in human autoimmune and inflammatory diseases.

ORCID:   0000-0002-4289-6998

 

ResearcherID:  D-5403-2017

 

10 representative publications out of >60

 

1. Xu H, Zhu J, Smith S, Foldi J, Zhao B, Chung AY, Outtz HH, Kitajewski J, Shi C, Weber S, Saftig P, Li YM, Ozato K, Blobel CP, Ivashkiv LB, Hu X. Notch-RBP-J signaling regulates IRF8 to promote inflammatory macrophage polarization. Nature Immunology 2012; 13:642-650

2. Shang Y, Coppo M, He T, Ning F, Yu L, Kang L, Zhang B, Ju C, Qiao Y, Zhao B, Gessler M, Rogatsky I, Hu X. The transcriptional repressor Hes1 attenuates inflammation by regulating transcription elongation. Nature Immunology 2016;17:930-937

3. Guo XK, Ou J, Liang S, Zhou X, Hu X. Epithelial Hes1 maintains gut homeostasis by preventing microbiota dysbiosis. Mucosal Immunology 2018; 11:716-726

4. Zhang X, Li X, Ning F, Shang Y, Hu X. TLE4 acts as a corepressor of Hes1 to inhibit inflammatory responses in macrophages. Protein & Cell 2019; 10:300-305

5. Liang S, Guo XK, Ou J, Huang R, Xue Q, Zhang B, Chung Y, Wu W, Dong C, Yang X, Hu X. Nutrient sensing by the intestinal epithelium orchestrates mucosal antimicrobial defense via translational control of Hes1. Cell Host & Microbe2019; 25:706-718 (cover story accompanied by a preview article)

6. Ning F, Li Y, Yu L, Zhang B, Liu Y, Zhao B, Shang Y, Hu X. Transcription factor Hes1 attenuates type I interferon-mediated immune responses via VEGF-C and WDFY1. Journal of Experimental Medicine 2019; 216:1396-1410

7. Ji L, Zhao X, Zhang B, Kang L, Song W, Zhao B, Xie W, Chen L, Hu X. Slc6A8-mediated creatine uptake and accumulation reprogram macrophage polarization via regulating cytokine responses. Immunity 2019; 51:272-284

8. Kang L, Zhang X, Ji L, Kou T, Smith SM, Zhao B, Guo X, Pineda-Torra I, Wu L, Hu X. The colonic macrophage transcription factor RBP-J orchestrates intestinal immunity against bacterial pathogens. Journal of Experimental Medicine 2020; 217(4). e20190762

9. Zhang X, Smith S, Zhao B, Wu L, Hu X. Three paralogous clusters of miR-17~92 family microRNAs restrain IL-12-mediated immune defense. Cellular and Molecular Immunology 2020. DOI: 10.1038/s41423-020-0363-5

10. Yu L, Zhang B, Sacta MA, Rollins DA, Chinenov Y, Li R, Rogatsky I, Hu X. Negative elongation factor complex enables macrophage-mediated inflammatory responses by controlling expression of anti-inflammatory genes. Nature Communications 2020; 11:2286

Research Team Alumni