数以百亿计的肠道菌在我们机体的作用是什么？我们的研究围绕这个令人着迷的问题开展。我们以肠道上皮为研究对象，探讨上皮细胞感知共生菌，调控肠道共生菌与机体自身生理活动的关键分子及通路，阐明这些通路在肠道稳态维持与损伤修复中的意义。

代表性论著：

 

1. Zhang Q, Pan Y, Zeng B, Zheng X, Wang H, Shen X, Li H, Jiang Q, Zhao J, Meng Z, Li P, Chen Z, Wei H*, Liu Z*. Intestinal Lysozyme Liberates Nod1 Ligands From Microbes to Direct Insulin Trafficking in Pancreatic Beta Cells. Cell Research. 2019 June; 29(7):516-532.(*共同通讯作者)

 

2. Wang H, Zhang X, Zuo Z, Zhang Q, Pan Y, Zeng B, Li W, Wei H, Liu Z. Rip2 Is Required for Nod2-Mediated Lysozyme Sorting in Paneth Cells. The Journal of Immunology. 2017 May 1; 198(9):3729-3736.

 

3. Yan R, Liu Z. LRRK2 enhances Nod1/2-mediated inflammatory cytokine production by promoting Rip2 phosphorylation. Protein & Cell. 2016 Jan; 8(1):55-66.

 

4. Zhang Q, Pan Y, Yan R, Zeng B, Wang H, Zhang X, Li W, Wei H*, Liu Z*. Commensal bacteria direct selective cargo sorting to promote symbiosis. Nature Immunology. 2015 Aug 3; 16: 918–926. (Cover story in Nature Immunology 2015, issue 16. Highlighted in "Living in harmony" at Nature Review Immunology 2015, 15, 527.) (*共同通讯作者)

 

5. Cho HJ, Yu J, Xie C, Rudrabhatla P, Chen X, Wu J, Parisiadou L, Liu G, Sun L, Ma B, Ding J, Liu Z*, Cai H*.Leucine-rich repeat kinase 2 regulates Sec16A at ER exit sites to allow ER-Golgi export. EMBO J. 2014 Sep. (*共同通讯作者)

 

6. Xing S, Luo Y, Liu Z, Bu P, Duan H, Liu D, Wang P, Yang J, Song L, Feng J, Yang D, Qin Z, Yan X. Targeting Endothelial CD146 Attenuates Colitis and Prevents Colitis-Associated Carcinogenesis. The American Journal of Pathology. 2014 184(5):1604-1616,

 

7. Liu Z, Lenardo MJ. The role of LRRK2 in inflammatory bowel disease. Cell Research. 2012 Jul;22(7):1092-4.

 

8. Liu Z, Lee J, Krummey S, Lu W, Cai H, Lenardo MJ. LRRK2 is a regulator of NFAT that modulates the severity of inflammatory bowel disease. Nature

 

9. Yu L, McPhee CK, Zheng L, Mardones GA, Rong Y, Peng J, Mi N, Zhao Y, Liu Z, Wan F, Hailey DW, Oorschot V, Klumperman J, Baehrecke EH, Lenardo MJ. Termination of autophagy and reformation of lysosomes regulated by mTOR. Nature. 2010 Jun 17; 465(7300): 942-6.

 

10. Lin X, Parisiadou L, Gu XL, Wang L, Shim H, Sun L, Xie C, Long CX, Yang WJ, Ding J, Chen ZZ, Gallant PE, Tao-Cheng JH, Rudow G, Troncoso JC, Liu Z, Li Z, Cai H. Leucine-rich repeat kinase 2 regulates the progression of neuropathology induced by Parkinson's-disease-related mutant alpha-synuclein. Neuron. 2009 Dec 24; 64(6): 807-27. Immunology. 2011 Oct 11; 12(11): 1063-70.

 

11. Liu Z, Meray RK, Grammatopoulos TN, Fredenburg RA, Cookson MR, Liu Y, Logan T, Lansbury PT Jr. Membrane-associated farnesylated UCH-L1 promotes alpah-synuclein neurotoxicity and is a therapeutic target for Parkinson’s disease. PNAS. 2009 Mar 24; 106(12): 4635-40.

 

12. Liu Z, Lenardo MJ. Reactive oxygen species regulate autophagy through redox-sensitive proteases. Dev Cell. 2007 Apr; 12(4): 484-5.

 

13. Yu L, Wan F, Dutta S, Welsh S, Liu Z, Freundt E, Baehrecke EH, Lenardo M. Autophagic cell death by selective catalase degradation. PNAS. 2006 Mar, 103(13): 4952-7.

 

14. Liu Y, Fallon L, Lashuel HA, Liu Z, Lansbury PT Jr. The UCH-L1 gene encodes two opposing enzymatic activities that affect alpha-synuclein degradation and Parkinson's disease susceptibility. Cell. 2002 Oct 18; 111(2): 209-18.

 

15. Ge H, Liu Z, Church GM, Vidal M. Correlation between transcriptome and interactome mapping data from Saccharomyces cerevisiae. Nat Genet. 2001 Dec; 29(4): 482-6.