Min Peng, Ph.D.

Phone: 86-10-62782882

Email: pengmin@tsinghua.edu.cn

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The laboratory of Min Peng

Min Peng, Ph.D.


2000-2005    B.M., Clinical Medicine

West China Medical Center, Sichuan University, Sichuan

2005-2010    Ph.D., Immunology

Peking Union Medical College, Beijing



2010-2014    Research Fellow

Immunology Program, Memorial Sloan Kettering Cancer Center, New York, United States

2014-2017    Research Associate

Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY, United States

2017-present Assistant Professor

School of Medicine, Tsinghua University, Beijing, China

2017-present Principal Investigator

Institute for Immunology, Tsinghua University, Beijing, China

2017-present, Principal Investigator

Center for Life Sciences, Beijing, China


Honors & awards:

2019  Outstanding Young Scholar Award, Qiu-Shi Science & Technologies Foundation

2018  Bayer Scholar

2018  Awardee of National 1000 Talent Program

2015 Postdoctoral Researcher Award, Memorial Sloan Kettering Cancer Center



Lixia Wang, Ph.D.

Lixia Wang received her Ph.D. degree from University of Chinese Academy of Sciences in 2018, then joined Min Peng’s laboratory for post-doctoral research. Her research focuses on the genetic modification of chimeric antigen receptor (CAR) T cell for adoptive cancer immunotherapy.


Xiaocui Zhao, Ph.D.

Xiaocui Zhao obtained her Ph.D. degree in cell biology from Zhejiang University and joined in Peng lab in 2018. Her research mainly focuses on CAR-T therapy.


Qiuping Zhou, Ph.D.

Qiuping Zhou is from Guangxi Zhuang Autonomous Region, and joined in Peng's lab as a postdoc in May 2021, got her Doctor of Immunology at Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, in January 2021. Her research focuses on CAR-T therapy.


Ying Liu

Ying Liu joined Peng's laboratory as a Ph.D student in 2017,with a bachelor's degree from Sichuan University. She worked on projects about mTOR, T cell proliferation and Calcium signal successively during doctoral training.


Hanfei Zhao

PhD student, his research focuses on Immunotherapeutic target discovery by genome-wide in vivo CRISPR screens in primary mouse T cells.


Guangyue Zhang

After graduated from School of Pharmaceutical Science, he joined the Lab of Dr. Min Peng at Institute of Immunology, Tsinghua University. During the Ph.D. training, Guangyue’s major research interest is the function, differentiation and fine-tuning co-receptor signaling in T cells. He is good at setting up and carrying out CRISPR based screening assays in both cell lines and primary T cells. Besides daily training, he is often playing tennis with friends as an amateur.


Gang Jin

Ph.D student (From2017) in PTN. Research focuses: Adoptive T cell therapy against cancer and autoimmune disease; Nutrient sensing pathway regulation of HSC function.


Yuying Ma

Yuying Ma, PhD student (since 2018) in School of Medicine, Bachelor’s degree from Wuhan University. Research focus: immune metabolism.


Jing Xu

Jing Xu, PhD student (from 2018). Get his bachelor's degree from Soochow  University. Currently, he mainly focuses on the research of calcium signaling in T cell biology and deciphers the role of calcium in T cell homeostasis.


Zihao He

He Zihao joined Peng's laboratory in 2019 as a PhD student. He has been dedicated to the research on genetic modification in Treg cells for adoptive cell transfer.


Qing Shang

Qing Shang joined Peng lab in September, 2020, for research training as part of her MD program. With an interest in immunometabolism and metabolism in general, she is now focusing on the role of short chain fatty acids in physiological and pathological settings.


Xiaonan Ma

Xiaonan Ma, a PhD student (from 2020) in PTN. She obtained the bachelor degree in animal medicine from Jilin University. And her research interest is the mechanism of T cell memory formation.


Yun Yu

PhD student (since 2020) in Institute for Immunology of Tsinghua University. Received Bachlor's Degree (majored in Chemical Biology) from Xi'an Jiaotong University. Her research focuses on the interaction between CAR-T and the endogenous immune system. Likes photography.


Yanyan Liu

Yanyan Liu, a PhD student of class 2020, joined Peng Lab. after got his bachelor's degree from Sichuan University. Currently, he mainly focuses on the research of CAR-T targeted therapy. He is trying to change from a “naive” student to a “functional” and “productive” “effector” student.


Yibo Zheng

As a student of Doctor of Medicine (M.D.) major in Clinical Medicine, I joined the lab for the two-year scientific research training during my eight-year curriculum. My current research focuses on the functional genomics in primary T cells.


Research Interests:

My laboratory is committed to advancing T cell research, with a dual focus on elucidating the foundational biology of T cells and exploring their therapeutic potential in combating diseases. Our primary objective is to unravel the intricate mechanisms governing T cell expansion, contraction, persistence, and memory formation. Leveraging state-of-the-art technologies, we have recently achieved a groundbreaking milestone by inducing a novel state in T cells, termed Immortal-like and Functional (TIF). These reprogrammed TIF cells exhibit remarkable attributes, combining the near-limitless stemness reminiscent of iPSCs with the functional capabilities of mature T cells. This unique phenotype empowers them with unparalleled efficacy against various ailments, including tumors, viral infections, and numerous chronic diseases.

Presently, we are deeply engaged in investigating the underlying mechanisms and exploring the clinical applications of TIF. We are actively seeking postdoctoral fellows with a keen interest in T cell biology and immunotherapy, please reach out to us at pengmin@tsinghua.edu.cn.

ORCID: 0000-0002-5885-0660


ResearcherID: O-3770-2017



  1. 1. Gang Jin*, Yanyan Liu*, Lixia Wang, Zihao He, Xiaocui Zhao, Yuying Ma, Yuting Jia, Zhuoyang Li, Na Yin, Min Peng. A single infusion of engineered long-lived and multifunctional T cells confers durable remission of asthma in mice. Nat Immunol. 2024. Accepted.
  2. 2. Lixia Wang*, Gang Jin*,Qiuping Zhou*, Yanyan Liu, Xiaocui Zhao, Zhuoyang Li, Na Yin, Min Peng. Induction of immortal-like and functional CAR T cells by defined factors. J Exp Med. 2024. In press 
  3. 3. Ying Liu*, Yuying Ma*, Jing Xu*, Guangyue Zhang*, Xiaocui Zhao*, Zihao He, Lixia Wang, Na Yin, Min Peng. VMP1 prevents Ca2+ overload in endoplasmic reticulum and maintains naive T cell survival. J Exp Med. 2023 Jun 5;220(6):e20221068.
  4. 4. Min Peng, Ming O. Li. Metabolism along the life journey of T cells. Life Metabolism. 2023, 002(001)
  5. 5. Na Yin*, Gang Jin*, Yuying Ma, Hanfei Zhao, Guangyue Zhang, Ming O. Li, Min Peng. SZT2 maintains hematopoietic stem cell homeostasis via nutrient-mediated mTORC1 regulation. J Clin Invest., 2022 Oct 17, 130(20):e146272.
  6. 6. Hanfei Zhao, Ying Liu, Lixia Wang, Gang Jin, Xiaocui Zhao, Jing Xu, Guangyue Zhang, Yuying Ma, Na Yin, Min Peng. Genome-wide fitness gene identification reveals Roquin as a potent suppressor of CD8 T cell expansion and anti-tumor immunity. Cell Reports. 2021 Dec 7;37(10):110083.
  7. 7. Ke Xu*, Na Yin*, Min Peng, Efstathios G Stamatiades, Sagar Chhangawala, Amy Shyu, Peng Li, Xian Zhang, Mytrang H Do, Kristelle J Capistrano, Chun Chou, Christina S Leslie, Ming O Li. Glycolytic ATP fuels phosphoinositide 3-kinase signaling to support effector T helper 17 cell responses. Immunity. 2021. 54(5):976-87.
  8. 8. Ke Xu, Na Yin, Min Peng, Efstathios G Stamatiades, Amy Shyu, Peng Li, Xian Zhang, Mytrang H Do, Zhaoquan Wang, Kristelle J Capistrano, Chun Chou, Andrew G Levine, Alexander Y Rudensky, Ming O Li. Glycolysis fuels phosphoinositide 3-kinase signaling to bolster T cell immunity. Science. 2021. Jan 22;371(6527):405-10.
  9. 9. Mytrang H. Do,  Xinxin Wang,  Xian Zhang,  Chun Chou,  Briana G. Nixon,  Kristelle J. Capistrano, Min Peng, Alejo Efeyan, David M. Sabatini, Ming O. Li. Nutrient mTORC1 signaling underpins regulatory T cell control of immune tolerance. J Exp Med. 2020 Jan 6;217(1):e20190848.
  10. 10. Min Peng, Na Yin, Ming O. Li. SZT2 dictates GATOR control of mTORC1 signaling. Nature. 2017 Mar 16;543(7645):433-437.
  11. 11. Min Peng*, Na Yin*, Sagar Chhangawala, Ke Xu, Christina S. Leslie, Ming O. Li. Aerobic glycolysis promotes T helper 1 cell differentiation through an epigenetic mechanism. Science, 2016 Oct 28; 354(6311): 481-484.
  12. 12. Jiangbin Ye, Wilhelm Palm, Min Peng, Bryan King, Tullia Lindsten, Ming O. Li, Constantinos Koumenis, Craig B. Thompson. GCN2 sustains mTORC1 suppression upon amino acid deprivation by inducing Sestrin2. Genes Dev. 2015 Nov 15; 29 (22): 2331-6.
  13. 13. Min Peng, Na Yin, Ming O. Li. Sestrins Function as Guanine Nucleotide Dissociation Inhibitors for Rag GTPases to Control mTORC1 Signaling. Cell. 2014 Sep 25; 159(1): 122-33.
  14. 14. Weiming Ouyang, Will Liao, Chong T. Luo, Na Yin, Morgan Huse, Myoungjoo V. Kim, Min Peng, Pamela Chan, Qian Ma, Yifan Mo, Dies Meijer, Keji Zhao, Alexander Y. Rudensky, Gurinder Atwal, Michael Q. Zhang, Ming O. Li. Novel Foxo1-dependent transcriptional programs control Treg cell function. Nature. 2012 Nov 22; 491(7425): 554-9
  15. 15. Min Peng,Sha Guo,Na Yin, Jing Xue, Lian Shen, Qing Zhao, Wei Zhang. Ectodomain shedding of Fcalpha receptor is mediated by ADAM10 and ADAM17. Immunology, 2010, 130(1): 83-91
  16. 16. Min Peng; Na Yin; Wei Zhang. Endocytosis of FcaR is clathrin and dynamin dependent but its cytoplasmic domain is not required. Cell Res, 2009, 20(2): 223-237

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