研究领域

 

主要研究领域是天然免疫，包括巨噬细胞活化与功能的调控以及肠道上皮细胞在稳态维持和宿主防御中的作用。具体研究方向如下：

 

1. 调控巨噬细胞活化及极化的分子机制
2. 组织定居巨噬细胞生物学
3. 肠道上皮细胞功能调控机制
4. 自身免疫与炎症性疾病的新型治疗方法与靶点研究

 

关键词：

巨噬细胞，炎症，自身免疫，肠道上皮细胞

ORCID:   0000-0002-4289-6998

 

ResearcherID:  D-5403-2017

 

10 representative publications out of >60：

 

1. Xu H, Zhu J, Smith S, Foldi J, Zhao B, Chung AY, Outtz HH, Kitajewski J, Shi C, Weber S, Saftig P, Li YM, Ozato K, Blobel CP, Ivashkiv LB, Hu X. Notch-RBP-J signaling regulates IRF8 to promote inflammatory macrophage polarization. Nature Immunology 2012; 13:642-650

 

2. Shang Y, Coppo M, He T, Ning F, Yu L, Kang L, Zhang B, Ju C, Qiao Y, Zhao B, Gessler M, Rogatsky I, Hu X. The transcriptional repressor Hes1 attenuates inflammation by regulating transcription elongation. Nature Immunology 2016;17:930-937

 

3. Guo XK, Ou J, Liang S, Zhou X, Hu X. Epithelial Hes1 maintains gut homeostasis by preventing microbiota dysbiosis. Mucosal Immunology 2018; 11:716-726

 

4. Zhang X, Li X, Ning F, Shang Y, Hu X. TLE4 acts as a corepressor of Hes1 to inhibit inflammatory responses in macrophages. Protein & Cell 2019; 10:300-305

 

5. Liang S, Guo XK, Ou J, Huang R, Xue Q, Zhang B, Chung Y, Wu W, Dong C, Yang X, Hu X. Nutrient sensing by the intestinal epithelium orchestrates mucosal antimicrobial defense via translational control of Hes1. Cell Host & Microbe2019; 25:706-718 (cover story accompanied by a preview article)

 

6. Ning F, Li Y, Yu L, Zhang B, Liu Y, Zhao B, Shang Y, Hu X. Transcription factor Hes1 attenuates type I interferon-mediated immune responses via VEGF-C and WDFY1. Journal of Experimental Medicine 2019; 216:1396-1410

 

7. Ji L, Zhao X, Zhang B, Kang L, Song W, Zhao B, Xie W, Chen L, Hu X. Slc6A8-mediated creatine uptake and accumulation reprogram macrophage polarization via regulating cytokine responses. Immunity 2019; 51:272-284

 

8. Kang L, Zhang X, Ji L, Kou T, Smith SM, Zhao B, Guo X, Pineda-Torra I, Wu L, Hu X. The colonic macrophage transcription factor RBP-J orchestrates intestinal immunity against bacterial pathogens. Journal of Experimental Medicine 2020; 217(4). e20190762

 

9. Zhang X, Smith S, Zhao B, Wu L, Hu X. Three paralogous clusters of miR-17~92 family microRNAs restrain IL-12-mediated immune defense. Cellular and Molecular Immunology 2020. DOI: 10.1038/s41423-020-0363-5

 

10. Yu L, Zhang B, Sacta MA, Rollins DA, Chinenov Y, Li R, Rogatsky I, Hu X. Negative elongation factor complex enables macrophage-mediated inflammatory responses by controlling expression of anti-inflammatory genes. Nature Communications 2020; 11:2286