免疫反应及炎症调控

代谢的神经免疫调控网络

神经系统免疫稳态

ORCID: 0000-0001-8544-3318

 

ResearcherID: D-7276-2017

 

代表性论著：

 

1. Hu Z^#, Deng N^#, Liu K, Zhou N, Sun Y, Zeng W*. CNTF-STAT3-IL-6 axis mediates neuroinflammatory cascade across Schwann cell-neuron-microglia. Cell Reports. 2020 May 19; 31(7):107657. (^#first-authors contributed equally)

 

2. Meng X, Zeng W, Young SG*, Fong LG. GPIHBP1, a partner protein for lipoprotein lipase, is expressed only in capillary endothelial cells. Journal of Lipid Research. 2020 Mar 4; pii: jlr.ILR120000735.

 

3. Hu Z. Deng N, Liu K, Zeng W*. DLK mediates the neuronal intrinsic immune response and regulates glial reaction and neuropathic pain. Experimental Neurology. 2019 Dec; 322: 113056.

 

4. Hu Z. and Zeng W*. Splenic leukocytes get the nerves up for myelopoiesis. Immunity. 2018 Jul 17; 49(1): 1-3. (preview)

 

5. Cao Y^#, Wang H^#, Wang Q, Han X, Zeng W*. Three-dimensional volume fluorescence-imaging of vascular plasticity in adipose tissues. Molecular Metabolism. 2018 Aug; 14:71-81. (^#first-authors contributed equally)

 

6. Wang Q^#, Zhang S^#, Liu T^#, Wang H, Liu K, Wang Q, Zeng W*. Sarm1/Myd88-5 regulates neuronal intrinsic immune response to traumatic axonal injuries. Cell Reports. 2018 Apr 17; 23(3): 716-724. (^#first-authors contributed equally)

 

7. Cao Y, Wang H, Zeng W*. Whole-tissue 3D imaging reveals intra-adipose sympathetic plasticity regulated by NGF-TrkA signal in cold-induced beiging. Protein & Cell. 2018 Jun; 9(6): 527-539.

 

8. Jiang H^#, Ding X^#, Cao Y, Wang H, Zeng W*. Dense intra-adipose sympathetic arborizations are essential for cold-induced beiging of mouse white adipose tissues. Cell Metabolism. 2017 Oct 3; 26(4): 686-692.e3. (^#first-authors contributed equally)

 

9. Zhang S, Li N, Zeng W, Gao N*, Yang M*. Cryo-EM structures of the mammalian endo-lysosomal TRPML1 channel elucidate the combined regulation mechanism. Protein & Cell. 2017 Nov 21;8(11): 834-847.

 

10. Zeng W^#, Pirzgalska RM^#, Pereira MM, Kubasova N, Barateiro A, Seixas E, Lu YH, Kozlova A, Voss H, Martins GG, Friedman JM, Domingos AI*. Sympathetic neuro-adipose connections mediate leptin-driven lipolysis. Cell. 2015 Sep 24; 163(1): 84-94. (^#first-authors contributed equally)

 

11. Peng Y^#, Zeng W^#, Ye H, Han KH, Dharmarajan V, Novick S, Wilson IA, Griffin PR, Friedman JM, Lerner RA*. A general method for insertion of functional proteins within proteins via combinatorial selection of permissive junctions. Chem Biol. 2015 Aug 20; 22(8): 1134-43. (^#first-authors contributed equally)

 

12. Zeng W^#, Lu YH^#, Lee J, Friedman JM*. Reanalysis of parabiosis of obesity mutants in the age of leptin. Proc Natl Acad Sci U S A. 2015 Jul 21; 112(29):E3874-82. (*first-authors contributed equally)

 

13.  Glasmacher E^#, Agrawal S^#, Chang AB^#, Murphy TL^#, Zeng W^#, Vander Lugt B, Khan AA, Ciofani M, Spooner CJ, Rutz S, Hackney J, Nurieva R, Escalante CR, Ouyang W, Littman DR, Murphy KM*, Singh H*. A genomic regulatory element that directs assembly and function of immune-specific AP-1-IRF complexes. Science. 2012 Nov 16; 338(6109): 975-80. (^#first-authors contributed equally)

 

14. Rutz S, Noubade R, Eidenschenk C, Ota N, Zeng W, Zheng Y, Hackney J, Ding J, Singh H, Ouyang W*. Transcription factor c-Maf mediates the TGF-b-dependent suppression of IL-22 production in T(H)17 cells. Nat Immunol. 2011 Oct 16; 12(12): 1238-45.

 

15. Zeng W^#, Sun L^#, Jiang X, Chen X, Hou F, Adhikari A, Xu M, Chen ZJ*. Reconstitution of the RIG-I pathway reveals a signaling role of unanchored polyubiquitin chains in innate immunity. Cell. 2010 Apr 16; 141(2): 315-30. (^#first-authors contributed equally)

 

16. Zeng W, Xu M, Liu S, Sun L, Chen ZJ*. Key role of Ubc5 and lysine-63 polyubiquitination in viral activation of IRF3. Mol Cell. 2009 Oct 23; 36(2): 315-25.

 

17.  Zeng W, Chen ZJ*. MITAgating viral infection. Immunity. 2008 Oct 17; 29(4): 513-5.

 

18. Xu M, Skaug B, Zeng W, Chen ZJ*. A ubiquitin replacement strategy in human cells reveals distinct mechanisms of IKK activation by TNFalpha and IL-1beta. Mol Cell. 2009 Oct 23; 36(2): 302-14.

 

19. Xia ZP, Sun L, Chen X, Pineda G, Jiang X, Adhikari A, Zeng W, Chen ZJ*. Direct activation of protein kinases by unanchored polyubiquitin chains. Nature. 2009 Sep 3; 461(7260): 114-9.

 

20. Yang M, Xu G, Li S, Sun L, Shi N, Zeng W, Pang H, Zhang W, Rao Z*. Crystallization and preliminary crystallographic analysis of the extracellular fragment of FcalphaRI/CD89. Acta Crystallogr D Biol Crystallogr. 2003 59(Pt 12): 2251-3.

 

21. Sun ZH, Lai YL, Zeng WW, Zhao D, Ye ZW, Zuo HC, Xie ZP*. Mesencephalic progenitors can improve rotational behavior and reconstruct nigrostriatal pathway in PD rats. Acta Neurochir Suppl. 2003 87:175-80.

 

22. Sun ZH, Lai YL, Zeng WW, Zhao D, Zuo HC, Xie ZP*. Neural stem/progenitor cells survive and differentiate better in PD rats than in normal rats. Acta Neurochir Suppl. 2003 87:169-74.