免疫学/肿瘤免疫学/NK细胞基础生物学和应用研究

代表性论著：

 

1. Chen S, Li Z, Cai C, Liu GW, Wang Y, Blonska M, Dan Li D, Du J, Lin X, Yang M, and Dong Z*. Dissection of SAP-dependent and SAP-independent SLAM Family Signaling in NKT Cell Development and Humoral Immunity, Journal Experimental Medicine. 2017 Feb;214(2):475-489.

 

2. Chen S, Yang M, Du J, Li D, Li ZH, Cai C, Ma Y, Zhang Y, Tian Z^*, and Dong Z^*. The self-specific activation receptor SLAM family is critical to NK cell education. Immunity. 2016, 45(2): 292-304.

 

3.Yang M, Chen S, Du J, He J, Wang Y, Zehua, Li Z, Liu G, Peng W, Zeng X, Li D, Xu P, Guo W, Chang Z, Wang S, Tian Z and Dong Z*. NK cell development requires Tsc1-dependent negative regulation of IL-15-trgiggered mTORC1 activation. Nature Communications. 2016 Sep 7;7:12730

 

4. Du J, Yang MX, Chen SS, Li D, Chang Z, and Dong Z* PDK1 promotes tumor growth and metastasis in a spontaneous breast cancer model. Oncogene, 2016;35(25):3314-23.

 

5. Yang M, Li D, Chang Z, Yang Z, Tian Z, Dong Z*. PDK1 orchestrates early NK cell development through induction of E4BP4 expression and maintenance of IL-15 responsiveness. Journal Experimental Medicine. 2015 212(2):253-65.

 

6. Dong Z*, Davidson D, Pérez-Quintero L.A, Kurosaki T, Swat W, and Veillette A. The Adaptor SAP Controls NK Cell Activation by Regulating the Enzymes Vav-1 and SHIP-1 and by Enhancing Conjugates with Target Cells. Immunity, 2012; 36(6):974-85.

 

7. Dong Z, Veillette A. How do SAP family deficiencies compromise immunity? Trends in Immunology; 2010 Aug;31(8):295-302

 

8. Dong Z, Cruz-Munoz ME, Zhong M, Chen R, Latour S and Veillette A. Essential role of SAP family adaptors in natural killer cell surveillance of hematopoietic cells. Nature Immunology; 10(9); (2009):973-80.