研究项目:

• 天然淋巴样细胞的发育和功能研究
• 肠道相关淋巴组织的发育机制
• 天然免疫系统、获得性免疫系统、肠道菌群和食物间的相互作用及对肠道稳态的调节
• 黏膜免疫微环境在肠道感染、炎症性肠病、肥胖、肿瘤等相关疾病中的作用及机制 

Researcher ID : I-3710-2017

 

ORCID  : 0000-0001-5152-3010

 

代表性论著：

 

1. Yuan Zhang, Tae-Jin Kim, Joanna A Wroblewska, Vera Tesic, Vaibhav Upadhyay, Ralph R Weichselbaum, Alexei V Tumanov, Hong Tang, Xiaohuan Guo, Haidong Tang, Yang-Xin Fu. Type 3 innate lymphoid cell-derived lymphotoxin prevents microbiota-dependent inflammation. Cellular & Molecular Immunology (2017) 14, 1–13.

 

2. Joanna A. Wroblewska, Yuan Zhang, Haidong Tang, Xiaohuan Guo, Cathryn Nagler, Yang-Xin Fu. Cutting Edge: Lymphotoxin Signaling Is Essential for Clearance of Salmonella from the Gut Lumen and Generation of Anti-Salmonella Protective Immunity. J Immunol (2016) 198 (1):55-60.

 

3. Yaoyao Shi, Weiwei Wu, Qian Chai, Qingqing Li, Yu Hou, Huan Xia, Boyang Ren, Hairong Xu, Xiaohuan Guo, Caiwei Jin, Mengjie Lv, Zhongnan Wang, Yang-Xin Fu, Mingzhao Zhu. LTβR controls thymic portal endothelial cells for haematopoietic progenitor cell homing and T-cell regeneration. Nature Communications (2016) 7, 12369.

 

4. Erin C. Zook, Kevin Ramirez, Xiaohuan Guo, Grant van der Voort, Mikael Sigvardsson, Eric C. Svensson, Yang-Xin Fu, Barbara L. Kee. The ETS1 transcription factor is required for the development and cytokine-induced expansion of ILC2. J Exp Med (2016) 213(5):687-96

 

5. Xiaohuan Guo, Yang-Xin Fu. The tragic fate of group 3 innate lymphoid cells during HIV-1 infection. J Clin Invest (2015) 125(9):3430-2

 

6. Xiaohuan Guo*, Yong Liang, Yuan Zhang, Anna Lasorella, Barbara L. Kee, Yang-Xin Fu*. Innate Lymphoid Cells Control Early Colonization Resistance against Intestinal Pathogens through ID2−Dependent Regulation of Microbiota. Immunity (2015) 42(1): 731–743. (* Correspondence)

 

7. Tony C. Tu, Nicholas K. Brown, Tae-Jin Kim, Joanna Wroblewska, Xuanming Yang, Xiaohuan Guo, Seoyun Hyunji Lee, Vinay Kumar, Kyung-Mi Lee, and Yang-Xin Fu. CD160 is essential for NK-mediated IFN-γ production. J Exp Med (2015) 212(3):415-29

 

8.Ting Li, Xiaohuan Guo, Wenyan Wang, Xiaoning  Mo, Pingzhang Wang, Wenling Han. Vset and transmembrane domaincontaining 1 is silenced in human hematopoietic malignancy cell lines with promoter methylation and has inhibitory effects on cell growth. Mol Med Rep (2015) 11(2):1344-51

 

9. Xiaohuan Guo, Ju Qiu, Tony Tu, Xuanming Yang, Liufu Deng, Robert A. Anders, Liang Zhou, and Yang-Xin Fu. Induction of Innate Lymphoid Cell-Derived Interleukin-22 by the Transcription Factor STAT3 Mediates Protection against Intestinal Infection. Immunity (2014) 40(1): 25–39

 

10. H Li, J Li, Y Su, Y Fan, X Guo, L Li, X Su, R Rong, J Ying, X Mo, K Liu, Z Zhang, F Yang, G Jiang, J Wang, Y Zhang, D Ma, Q Tao and W Han. A novel 3p22.3 gene CMTM7 represses oncogenic EGFR signaling and inhibits cancer cell growth. Oncogene (2014) 33: 3109–3118

 

11. Ju Qiu, Xiaohuan Guo, Zong-ming E. Chen, Lei He, Gregory F. Sonnenberg, David Artis, Yang-Xin Fu, Liang Zhou. Group 3 Innate Lymphoid Cells Inhibit T-Cell-Mediated Intestinal Inflammation through Aryl Hydrocarbon Receptor Signaling and Regulation of Microflora. Immunity (2013) 39(2):386-99

 

12. Xiaohuan Guo, Yanfei Zhang, Pingzhang Wang, Ting Li, Weiwei Fu, Xiaoning Mo, Taiping Shi, Zhixin Zhang, Yingyu Chen, Dalong Ma, Wenling Han. VSTM1-v2, a novel soluble glycoprotein, promotes the differentiation and activation of Th17 cells. Cellular Immunology (2012) 278(1-2):136-42

 

13. Ju Qiu, Jennifer J. Heller, Xiaohuan Guo, Zong-ming E. Chen, Kamonwan Fish, Yang-Xin Fu, Liang Zhou. The Aryl Hydrocarbon receptor regulates gut immunity through modulation of innate lymphoid cells. Immunity (2012) 36(1): 92-104

 

14. Alexei V. Tumanov, Ekaterina P. Koroleva, Xiaohuan Guo, Yugang Wang, Andrei Kruglov, Sergei Nedospasov, Yang-Xin Fu. Lymphotoxin Controls the IL-22 Protection Pathway in Gut Innate Lymphoid Cells during Mucosal Pathogen Challenge. Cell Host & Microbe (2011) 10: 44–53

 

15. Jihong Niu, Henan Li, Yao Zhang, Jinlan Li, Min Xie, Lingdi Li, Xiaoying Qin, Yazhen Qin, Xiaohuan Guo, Qian Jiang, Yanrong Liu, Shanshan Chen, Xiaojun Huang, Wenling Han, Guorui Ruan. Aberrant expression of CKLF-like MARVEL transmembrane member 5 (CMTM5) by promoter methylation in myeloid leukemia. Leukemia Research (2011) 35: 771–776

 

16. Tian L, Li W, Wang J, Zhang Y, Zheng Y, Qi H, Guo X, Zhang Y, Ma D, Shen H, Wang Y. The CKLF1-C19 peptide attenuates allergic lung inflammation by inhibiting CCR3- and CCR4-mediated chemotaxis in a mouse model of asthma. Allergy (2011) 66: 287–297

 

17. Henan Li*, Xiaohuan Guo*, Luning Shao, Markus Plate, Xiaoning Mo, Yu Wang & Wenling Han. (2010) CMTM5-v1, a four-transmembrane protein, presents a secreted form released via a vesicle-mediated secretory pathway. BMB reports 43(3): 182-187(*, Co-first Author)

 

18. Xiaohuan Guo, Ting Li, Yu Wang, Luning Shao, Yingmei Zhang, Dalong Ma, Wenling Han. (2009) CMTM5 induces apoptosis of pancreatic cancer cells and has synergistic effects with TNF-α. Biochem Biophys Res Commun 387: 139–142

 

19. Luning Shao, Xiaohuan Guo, Markus Plate, Ting Li, Yu Wang, Dalong Ma, Wenling Han. (2009) CMTM5-v1 induces apoptosis in cervical carcinoma cells. Biochem Biophys Res Commun 379: 866-8711